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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Link to relevant study record(s)

bioaccumulation in aquatic species: fish
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance has a low potential for bioaccumulation based on log Kow <=3
Reason / purpose for cross-reference:
data waiving: supporting information

Description of key information

log BCF = 0.5 (estimated based on an experimental log Pow of 1.1) (ECT, 2009)

Key value for chemical safety assessment

BCF (aquatic species):
3.162 dimensionless

Additional information

In accordance with column 2 of Annex IX, the study does not need to be conducted if the substance has a low potential for bioaccumulation. The log Kow of 1.1 for isobutyric acid (OXEA, 2009) indicates a low potential for bioaccumulation. Therefore and for reasons of animal welfare a fish study is not performed.

The log BCF of isobutyric acid was estimated to be 0.5 (BCF = 3.162) using the program BCFBAF v3.00 (Part of US EPA EPI Suite v4.00). In addition, a log BAF (upper trophic) of 0.31 (BAF = 2.06) was calculated using the method of Arnot-Gobas (ECT, 2010). The low BCF/BAF values indicate a low potential of isobutyric acid for bioaccumulation in aquatic organisms.

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