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EC number: 484-470-6 | CAS number: 623-40-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 51.54 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 6
- Dose descriptor starting point:
- NOAEC
- Value:
- 615.4 mg/m³
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 309.24 mg/m³
- Explanation for the modification of the dose descriptor starting point:
NOAEC = 149 ppm corresponding to 615.4 mg/m³ (at 25°C and 1013 mbar). Two starting point modifications were accounted for: 1) duration of exposure for workers is 8 h, whereas the test animals were exposed for 6h --> dose descriptor * 0.75. 2) Difference in inhalation volume of workers --> dose descriptor * 0.67. Corrected NOAEC: 309.24 mg/m³.
- AF for dose response relationship:
- 1
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 1 may be supported as a NOAEC was established in the study.
- AF for differences in duration of exposure:
- 2
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 2 may be used for duration extrapolation (i.e., sub-chronic to chronic).
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- As per REACH guidance 8.4.3.1
- AF for other interspecies differences:
- 1
- Justification:
- In contrast to the recommendations of the ECHA Guidance, no additional factor of 2.5 for other interspecies differences was applied, as there is no evidence for interspecies differences in the general mode of action or kinetics (recommendation of the VCI Working group "Toxicology", 2008).
- AF for intraspecies differences:
- 3
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 3 may be supported taking also into account the toxicokinetic evaluation of other structurally similar oximes.
- AF for the quality of the whole database:
- 1
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 1 may be supported as the study is robust.
- AF for remaining uncertainties:
- 1
- Justification:
- No AF for remaining uncertainties deemed necessary.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.097 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 216
- Dose descriptor starting point:
- LOAEL
- Value:
- 15 mg/kg bw/day
- Modified dose descriptor starting point:
- LOAEL
- Value:
- 21 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
LOAELcorr = LOAELoral * (ABSoral-rat / ABSdermal-human) * (7 day exposure rat / 5 days exposure worker) = 15 mg/kg bw/day * (100%/100%) * 1.4 = 21 mg/kg bw/day.
ABSoral-rat = oral absorption rate in rats, ABSdermal-human = dermal absorption rate in humans.
- AF for dose response relationship:
- 3
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 3-10 may be supported as a LOAEL was established in the study. A factor of 3 is taken for assessment due to the fact that a clear concentration-dependent increase in severity and expansion in different organs was seen.
- AF for differences in duration of exposure:
- 6
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 6 may be used for duration extrapolation (i.e., subacute to chronic).
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- According to REACH guidance 8.4.3.1, a factor of 4 is appropriate for allometric scaling between rats and humans.
- AF for other interspecies differences:
- 1
- Justification:
- In contrast to the recommendations of the ECHA Guidance, no additional factor of 2.5 for other interspecies differences was applied, as there is no evidence for interspecies differences in the general mode of action or kinetics (recommendation of the VCI Working group "Toxicology", 2008).
- AF for intraspecies differences:
- 3
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 3 may be supported taking also into account the toxicokinetic evaluation of other structurally similar oximes.
- AF for the quality of the whole database:
- 1
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 1 may be supported as the study used as starting point is a reliable one, suitable for route-to route extrapolation.
- AF for remaining uncertainties:
- 1
- Justification:
- No AF for remaining uncertainties deemed necessary.
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 10.99 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 10
- Dose descriptor starting point:
- NOAEC
- Value:
- 615.4 mg/m³
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 109.9 mg/m³
- Explanation for the modification of the dose descriptor starting point:
NOAEC = 149 ppm corresponding to 615.4 mg/m³ (at 25 °C and 1013 mbar). Two starting point modifications were accounted for: 1) duration of exposure for consumers is 24 h, whereas the test animals were exposed for 6 h --> dose descriptor * 0.25. 2.) consumers are exposed 7 days/week, whereas the test animals were exposed 5 days/week --> dose descriptor * 0.71
Corrected NOAEC: 109.9 mg/m3
- AF for dose response relationship:
- 1
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 1 may be supported as a NOAEC was established in the study.
- AF for differences in duration of exposure:
- 2
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 2 may be used for duration extrapolation (i.e., sub-chronic to chronic).
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- As per REACH guidance 8.4.3.1
- AF for other interspecies differences:
- 1
- Justification:
- In contrast to the recommendations of the ECHA Guidance, no additional factor of 2.5 for other interspecies differences was applied, as there is no evidence for interspecies differences in the general mode of action or kinetics (recommendation of the VCI Working group "Toxicology", 2008).
- AF for intraspecies differences:
- 5
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 5 may be supported taking also into account the toxicokinetic evaluation of other structurally similar oximes.
- AF for the quality of the whole database:
- 1
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 1 may be supported as the study is robust.
- AF for remaining uncertainties:
- 1
- Justification:
- No AF for remaining uncertainties deemed necessary.
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.042 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 360
- Dose descriptor starting point:
- LOAEL
- Value:
- 15 mg/kg bw/day
- Modified dose descriptor starting point:
- LOAEL
- Value:
- 15 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
In the absence of study data for the dermal route, route-to-route extrapolation needed to be considered in the present case. Dose descriptor starting value for the dermal DNEL is equal to the one determined in the oral study as (in the absence of toxicokinetics information) it can be assumed that dermal absorption will not be higher than oral absorption.
- AF for dose response relationship:
- 3
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 3-10 may be supported as a LOAEL was established in the study. A factor of 3 is taken for assessment due to the fact that a clear concentration-dependent increase in severity and expansion in different organs was seen.
- AF for differences in duration of exposure:
- 6
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 6 may be used for duration extrapolation (i.e., subacute to chronic).
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- According to REACH guidance 8.4.3.1, a factor of 4 is appropriate for allometric scaling between rats and humans.
- AF for other interspecies differences:
- 1
- Justification:
- In contrast to the recommendations of the ECHA Guidance, no additional factor of 2.5 for other interspecies differences was applied, as there is no evidence for interspecies differences in the general mode of action or kinetics (recommendation of the VCI Working group "Toxicology", 2008).
- AF for intraspecies differences:
- 5
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 5 may be supported taking also into account the toxicokinetic evaluation of other structurally similar oximes.
- AF for the quality of the whole database:
- 1
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 1 may be supported as the study is used as starting point is a reliable one, suitable for route-to route extrapolation.
- AF for remaining uncertainties:
- 1
- Justification:
- No AF for remaining uncertainties deemed necessary.
Acute/short term exposure
- Hazard assessment conclusion:
- hazard unknown but no further hazard information necessary as no exposure expected
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.042 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 360
- Dose descriptor starting point:
- LOAEL
- Value:
- 15 mg/kg bw/day
- Modified dose descriptor starting point:
- LOAEL
- Value:
- 15 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
No starting point modification was necessary.
- AF for dose response relationship:
- 3
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 3-10 may be supported as a LOAEL was established in the study. A factor of 3 is taken for assessment due to the fact that a clear concentration-dependent increase in severity and expansion in different organs was seen.
- AF for differences in duration of exposure:
- 6
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 6 may be used for duration extrapolation (i.e., subacute to chronic).
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- According to REACH guidance 8.4.3.1, a factor of 4 is appropriate for allometric scaling between rats and humans.
- AF for other interspecies differences:
- 1
- Justification:
- In contrast to the recommendations of the ECHA Guidance, no additional factor of 2.5 for other interspecies differences was applied, as there is no evidence for interspecies differences in the general mode of action or kinetics (recommendation of the VCI Working group "Toxicology", 2008).
- AF for intraspecies differences:
- 5
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 5 may be supported taking also into account the toxicokinetic evaluation of other structurally similar oximes.
- AF for the quality of the whole database:
- 1
- Justification:
- As per REACH guidance 8.4.3.1, a factor of 1 may be supported as the study is robust.
- AF for remaining uncertainties:
- 1
- Justification:
- No AF for remaining uncertainties deemed necessary.
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- low hazard (no threshold derived)
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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