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Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Deviations:
not specified
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
Deviations:
not specified
GLP compliance:
yes (incl. QA statement)
Analytical monitoring:
yes
Details on sampling:
The test substance was spiked to each of the buffer solutions at a nominal concentration of approximately 50 mg/L using a spike solution in water. For the test at pH 4, the peak areas of the test substance were determined immediately after preparation (t = 0) and at several sampling points after t = 0. The pH of the test samples was determined at the beginning and the end of the test. For the test at pH 7, the samples were prepared and placed in water baths at the end of the working day. The pH of the test samples was determined at the beginning and the end of the test.
Buffers:
Buffers: Acetate buffer pH 4: solution of 16.6 % 0.05 M sodium acetate and 83.4% 0.05 M acetic acid Phosphate buffer pH 7: solution of 0.05 M potassium di-hydrogenphosphate adjusted to pH 7 using 1 N sodium hydroxide Borate buffer pH 9: solution of 0.05 M boric acid and 0.05 M potassium chloride ajusted to pH 9 using 1 N sodium hydroxide
Duration:
120 h
pH:
7
Duration:
120 h
pH:
4
Transformation products:
no
pH:
4
Temp.:
25 °C
DT50:
> 1 yr
pH:
7
Temp.:
25 °C
DT50:
> 1 yr
pH:
9
Temp.:
25 °C
DT50:
> 1 yr
Executive summary:

In all tests performed, a decrease in concentration was observed. At the end of the main tests, concentrations became stable at 50 -60% of the initial concentration. This indicates that equilibrium is formed and that this is not hydrolysis.

MPKO is therefore considered hydrolytically stable (i.e. half-life time of > 1 year at 25°C) at pH 4, pH 7 and pH 9.

Description of key information

The substance is considered hydrolytically stable (i.e. half-life time of > 1 year at 25°C) at pH 4, pH 7 and pH 9.

Key value for chemical safety assessment

Additional information

The abiotic degradation of 2-Pentanone oxime was tested in a study following OECD guideline 111 (GLP). Hydrolysis of the substance was tested at pH 4, 7 and 9 respectively. Hydrolysis of the substance was not observed. Thus the substance was considered hydrolytically stable (half-life time of > 1 year at 25°C).