Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Insufficient data is available to evaluate the available study fully.

Data source

Reference
Reference Type:
publication
Title:
Irritant potency of the principal chlorinated aliphatic solvents on the skin and ocular mucous membranes of rabbits.
Author:
Duprat P, Delsaut L and Gradiski D
Year:
1976
Bibliographic source:
Eur J Toxicol 3; 171-177.

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloroethylene
EC Number:
201-167-4
EC Name:
Trichloroethylene
Cas Number:
79-01-6
Molecular formula:
C2HCl3
IUPAC Name:
1,1,2-trichloroethene
Constituent 2
Reference substance name:
Trichloroethene
IUPAC Name:
Trichloroethene

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Results and discussion

In vivo

Irritant / corrosive response data:
Application of 0.1 ml of 99.5% pure trichloroethylene directly to the rabbit eye produced a mild-to-moderate conjunctivitis with some epithelial abrasions being noted on examination with fluorescein.
Other effects:
Microscopic examination on day seven revealed epithelial keratosis in the process of healing. The eye had returned to normal within two weeks.

Applicant's summary and conclusion