Registration Dossier
Registration Dossier
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EC number: 201-167-4 | CAS number: 79-01-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Insufficient data is available to evaluate the available study fully.
Data source
Reference
- Reference Type:
- publication
- Title:
- Irritant potency of the principal chlorinated aliphatic solvents on the skin and ocular mucous membranes of rabbits.
- Author:
- Duprat P, Delsaut L and Gradiski D
- Year:
- 1 976
- Bibliographic source:
- Eur J Toxicol 3; 171-177.
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Trichloroethylene
- EC Number:
- 201-167-4
- EC Name:
- Trichloroethylene
- Cas Number:
- 79-01-6
- Molecular formula:
- C2HCl3
- IUPAC Name:
- 1,1,2-trichloroethene
- Reference substance name:
- trichloroethene
- IUPAC Name:
- trichloroethene
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Results and discussion
In vivo
- Irritant / corrosive response data:
- Application of 0.1 ml of 99.5% pure trichloroethylene directly to the rabbit eye produced a mild-to-moderate conjunctivitis with some epithelial abrasions being noted on examination with fluorescein.
- Other effects:
- Microscopic examination on day seven revealed epithelial keratosis in the process of healing. The eye had returned to normal within two weeks.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
