Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Studies based on which the toxicokinetic behaviour of the substance can be derived, considered acceptable for assessment. Also peer-reviewed under Regulation 793/93.

Data source

Reference
Reference Type:
other: EU Risk Assessment Report (RAR)
Title:
Trichloroethylene
Author:
Rapporteur: United Kingdom, on behalf of the European Union
Year:
2004

Materials and methods

Principles of method if other than guideline:
Toxicokinetic studies

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloroethylene
EC Number:
201-167-4
EC Name:
Trichloroethylene
Cas Number:
79-01-6
Molecular formula:
C2HCl3
IUPAC Name:
1,1,2-trichloroethene
Constituent 2
Reference substance name:
Trichloroethene
IUPAC Name:
Trichloroethene

Administration / exposure

Route of administration:
other: Oral and Inhalation

Results and discussion

Main ADME results
Type:
other: see summary of studies in attachment
Results:
Studies in experimental animals have shown that trichloroethylene is rapidly and extensively absorbed by all routes of exposure. Once absorbed it readily distributes to all compartments within the body.

Applicant's summary and conclusion