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EC number: 201-807-2 | CAS number: 88-18-6
Table #: Mean irritant/corrosive response data for each animal at each observation time of each animal from the test
Score at time point / Reversibility
Max. score: 80
Max. score: 10
Max. score: 20
Max. score: 110
* = could not be evaluated; ** = iris score of days 1 and 7 not accounted
In an acute eye irritation study according to USA Interagency Regulatory Liaison Group (IRLG, January 1981) Guideline, 0.1 ml of o-tert.-Butylphenol was instilled into the left eye of six male albino rabbits (New Zealand White strain). Eyes were not washed afterwards. Animals then were observed after 2 hours as well as after 1, 2, 3, 4, and 7 days. Irritation was scored by the method Draize (modified) and Kay & Calandra.
Under the experimental conditions employed, all animals showed cornea pannus after 7 days, additionally 2 animals showed damage of the corneal epithelium. Therefore, the test substance is considered to causes serious eye damage.
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