Registration Dossier

Environmental fate & pathways

Hydrolysis

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Waiver, no hydrolysis expected

Key value for chemical safety assessment

Additional information

No data are available on hydrolysis of o-tert-butylphenol. The substance is an alkyl-substituted phenol derivative and has no functional groups that can be hydrolyzed, i.e. ester, amide or any substituents on the alkyl-groups or the aromatic ring that could be substituted by OH- ions under the condition of the guideline test on hydrolysis as function of pH (OECD 111, EU method C7). Therefore from the structure of the substance it can be deduced that it does not undergo abiotic degradation through hydrolysis and the study is scientifically unjustified.

A study on hydrolysis of the structural analogue, o-sec-butylphenol, is available. CITI (1999), in a study conducted according to OECD 211 methods, that no hydrolysis was measured at pH 4, 7, or 9. This study supports the waiver statement that the test substance is not expected to hydrolyze.