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Toxicological information

Repeated dose toxicity: dermal

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Administrative data

Endpoint:
repeated dose toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies
Remarks:
Staining study-not relevant

Data source

Reference
Reference Type:
publication
Title:
Yellow staining of skin among plastics workers
Author:
Cohen SR, and Ross PM
Year:
1988
Bibliographic source:
Arch. Dermatol., 124(1):19-20

Materials and methods

Principles of method if other than guideline:
Mice were exposed to the test substance dermally for 7 days.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
m-phenylenediamine, purity not reported

Test animals

Species:
mouse
Strain:
Balb/c

Administration / exposure

Details on exposure:
Route of Administration: dermal
Duration of treatment / exposure:
7 days
Frequency of treatment:
once per day
Doses / concentrations
Remarks:
Doses / Concentrations:
50 µL of a 44% (w/v) ethanol solution
Details on study design:
Test material was applied to the shaved-back skin of Balb/C mice, daily for seven days.

Results and discussion

Results of examinations

Details on results:
The test material did not stain the skin, but caused light yellow discoloration of the fur adjacent to the cutaneous application site after four days.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion