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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
significant methodological deficiencies
Remarks:
Very limited information on methodology and results reported. Non-standard method for acute toxicity testing.

Data source

Reference
Reference Type:
publication
Title:
Dominant lethal mutagenicity study on hair dyes
Author:
Burnett C, Loehr R, Corbett J
Year:
1977
Bibliographic source:
Journal of Toxicology and Environmental Health, 2:657-662

Materials and methods

Principles of method if other than guideline:
The acute toxicity of the test substance was examined in rats.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test substance (as cited in study): m-phenylenediamine

Test animals

Species:
rat
Strain:
other: Charles River CD
Sex:
male/female
Details on test animals and environmental conditions:
- Weight range: 200-300 g

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: 10% DMSO
No. of animals per sex per dose:
5 per group

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
283 mg/kg bw

Applicant's summary and conclusion