Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-058-1 | CAS number: 77-78-1
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
Threshold limit: 1 ppm (W.B. Deichmann and H.W. Gerarde; Toxicology of drugs and chemicals, 1969)
According to EU risk assessment report, 2002:
A theoretical Health-based Occupational Reference Value (HBORV) of 0.1 mg/m3is based on a fictive NOAEL of 9 mg/m3from a semi-chronic inhalation study, or a NOAEL of 0.9 mg/m3 from a chronic inhalation study. Comparison of these fictive NOAELs with the available toxicological data from repeated inhalation studies shows that NOAELs lower than 0.9 or 9 mg/m3for systemic toxic effects cannot be excluded. In a two-week inhalation study with rats exposed to concentration levels of 0.5, 3.7 and 6.3 mg/m3increased cell proliferation of nasal epithelium cells was seen at al dose levels. In the carcinogenicity study of Schlögel effects were observed at all dose levels (>2.6 mg/m3), and in the teratogenicity study the NOAEL for maternal toxicity amounted to 0.5 mg/m3. Therefore it cannot be excluded that a repeated-dose inhalation study with rats may lead to a NOAEL <0.9 or 9 mg/m3and thus a HBORV <0.1 mg/m3. However, the risk assessment for carcinogenic effects indicates that the occupational exposure limits should be lowered considerably. The reference concentrations associated with the target risk levels of 4.10-3and 4.10-5under occupational conditions of exposure amount to 9 and 0.09 μg/m3, respectively. Because DMS acts mainly locally at the place of first contact and the calculated reference values are rather low, it seems reasonable to assume that these concentrations are low enough to prevent adverse systemic effects.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
