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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Literature in Russian and only limited information available.

Data source

Reference
Reference Type:
publication
Title:
Pathogenesis of acute dimethyl sulphate poisoning (an experimental study).
Author:
Batsura, Y.D. et al.
Year:
1980
Bibliographic source:
Gig. Tr. Prof. Zabol. (1980), 55-57

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
During an inhalation experiment, rats were exposed to dimethyl sulphate for 4 hours. Macroscopic and microscopic examination were carried out.
This information was taken from European Union Risk Assessment Report, which deals with dimethyl sulphate.
(Reference: EU RAR "Dimethyl sulphate (CAS # 77-78-1, EC # 201-058-1). EUR 19838 EN. Institute for Health and Consumer Protection. ECB - Existing Substances. Final Report, 2002)
GLP compliance:
not specified
Test type:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Dimethyl sulphate
No further details are given.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
No data
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
No data
No. of animals per sex per dose:
No data
Control animals:
not specified
Details on study design:
Examination performed: "Groups of animals were sacrificed immediatley following exposure and at intervals thereafter"
This information was taken from the European Union Risk Assessment Report, which deals with dimethyl sulphate.
(Reference: EU RAR "Dimethyl sulphate (CAS # 77-78-1, EC # 201-058-1). EUR 19838 EN. Institute for Health and Consumer Protection. ECB - Existing Substances. Final Report, 2002)
Statistics:
No data

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
0.045 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Mortality:
No data
Clinical signs:
other: "Some animals had nasal discharge". This information was taken from the European Union Risk Assessment Report, which deals with dimethyl sulphate. (Reference: EU RAR "Dimethyl sulphate (CAS # 77-78-1, EC # 201-058-1). EUR 19838 EN. Institute for Health a
Body weight:
No data
Gross pathology:
"The rats were dyspneoic with cyanosis of the mucosae, hyperemia of the lung, and hemorrhage in the internal organs."
This information was taken from the European Union Risk Assessment Report, which deals with dimethyl sulphate.
(Reference: EU RAR "Dimethyl sulphate (CAS # 77-78-1, EC # 201-058-1). EUR 19838 EN. Institute for Health and Consumer Protection. ECB - Existing Substances. Final Report, 2002)
Other findings:
- Histopathology and electron microscopic examination: " Histological and eletron microscopic examination of lung tissue revealed hemorrhage and coagulated proteins in the alveoli. After a latent period of 5-6 hr, accumulation of edematous fluid in the air spaces developed progressively over 24 - 48 hr."
This information was taken from the European Union Risk Assessment Report, which deals with dimethyl sulphate.
(Reference: EU RAR "Dimethyl sulphate (CAS # 77-78-1, EC # 201-058-1). EUR 19838 EN. Institute for Health and Consumer Protection. ECB - Existing Substances. Final Report, 2002)

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category I
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LC50 (rats, 4 h) for dimethyl sulphate is 0.045 mg/l.
This information was taken from the European Union Risk Assessment Report, which deals with dimethyl sulphate.
(Reference: EU RAR "Dimethyl sulphate (CAS # 77-78-1, EC # 201-058-1). EUR 19838 EN. Institute for Health and Consumer Protection. ECB - Existing Substances. Final Report, 2002)
According to the criteria specified by Directive 67/548/EEC and subsequent regulations, the test item is classified as very toxic via the inhalation route.
According to the EC Regulation No. 1272/2008 and subsequent regulations, the test item is classified as Category 1.