Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

No studies on the EC substance [940-223-9] itself are available. A read-across approach using the very close structural analogue [938-147-6] Fatty acid chlorides, C8-14 (even numbered), reaction products with glycine (Public name: Sodium cocoyl glycinate (SCG)) as source substance was chosen.

Sodium cocoyl glycinate (SCG) was tested for a possible skin sensitizing potential in guinea pigs using the maximization method of Magnusson and Kligman according to OECD test guideline 406. Following intradermal and dermal induction using a 5% and 50% test concentration respectively, a dermal challenge treatment using 5% the registered substance in water under occlusive dressing was performed. No signs of cutaneous allergic responses were noted at 24 and 48 hours after removal of the dressing (sensitization incidence = 0%). Based hereupon, the registered substance is considered to have no skin sensitization potential. Based on the justified read-across these endpoint data for the source substance are also taken for the target substance.

Migrated from Short description of key information:
No studies on the EC substance [940-223-9] itself are available. A read-across approach using the very close structural analogue [938-147-6] Fatty acid chlorides, C8-14 (even numbered), reaction products with glycine (Public name: Sodium cocoyl glycinate (SCG)) as source substance was chosen.
The source substance does not induce any signs of sensitization in animals when tested in the maximization test according to Magnusson and Kligman.
Based on the justified read-across these endpoint data for the source substance are also taken for the target substance.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

No studies on the EC substance [940-223-9] itself are available. A read-across approach using the very close structural analogue [938-147-6] Fatty acid chlorides, C8-14 (even numbered), reaction products with glycine (Public name: Sodium cocoyl glycinate (SCG)) as source substance was chosen.

The source substance is not a skin sensitizer. None of the available toxicological data and known exposure conditions indicates concern that the source substance may possess respiratory sensitization properties.

Based on the justified read-across these endpoint data for the source substance are also taken for the target substance.


Migrated from Short description of key information:
No studies on the EC substance [940-223-9] itself are available. A read-across approach using the very close structural analogue [938-147-6] Fatty acid chlorides, C8-14 (even numbered), reaction products with glycine (Public name: Sodium cocoyl glycinate (SCG)) as source substance was chosen.
The source substance is not a skin sensitizer. None of the available toxicological data and known exposure conditions indicates concern that the registered substance may pose a respiratory sensitization risk.
Based on the justified read-across these endpoint data for the source substance are also taken for the target substance.

Justification for classification or non-classification

Based on all available data the source substance is not a skin sensitiser and therefore is not subject for classification and labelling requirements.

This conclusion is also taken for the target substance.