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Administrative data

Description of key information

A LOAEL of 325 mg/kg bw/day is taken from a chronic carcinogenicity study.

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LOAEL
325 mg/kg bw/day
Study duration:
chronic
Species:
rat
Quality of whole database:
The chronic study has a Klimisch score of 2, the read across has a Klimisch score of 2

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: inhalation - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
The chronic study is chosen because of the longer exposition period. Within the study two species where tested, the LOAEL in rats is chosen as it is the lower one.

Justification for classification or non-classification