Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-394-1 | CAS number: 95-14-7
Additional ecotoxological information
Administrative data
- Endpoint:
- additional ecotoxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Endocrine disrupting effects of benzotriazole in rare minnow (Gobiocypris rarus) in a sex-dependent manner
- Author:
- Liang, X.; Wang, M.; Chen, X.; Zha, J.; Chen, H.; Zhu, L.; Wang, Z.
- Year:
- 2 014
- Bibliographic source:
- Chemosphere, 112, 154-162
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Benzotriazole
- EC Number:
- 202-394-1
- EC Name:
- Benzotriazole
- Cas Number:
- 95-14-7
- Molecular formula:
- C6H5N3
- IUPAC Name:
- benzotriazole
- Reference substance name:
- Unknown impurities
- IUPAC Name:
- Unknown impurities
- Test material form:
- solid
- Details on test material:
- substance used in publications
Constituent 1
impurity 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Findings indicate that Benzotriazole could adversely affect rare minnows in a sex-dependent manner.
- Executive summary:
Adult chinese rare minnows were exposed to 0.05, 0.5 and 5 mg/L Benzotriazole for 28 days. At the highest test concentration pathological changes of the liver showing hypertrophy, nuclei pyknosis and vacuolization was observed. Furthermore, degradation of the ovary in female and stimulation of spermatogenesis in male fish were detected. The 17β-estradiol plasma level was significantly increased in males but decreased in females.
Up-regulation of CYP19B, GnRHs and LHβ mRNA in the brain was detected at all doses. In male gonads, the transcriptional levels of StAR, CYP11A, 3βHSD, CYP17, 17βHSD, and CYP19A were decreased at the highest dose. Most of these genes, except 3βHSD, were increased in females at all test concentrations. Additionally, the expression level of vitellogenin in the livers in all groups was significantly increased in comparison to the control group.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
