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Long-term toxicity to aquatic invertebrates

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Description of key information

The results of the 21-day chronic toxicity study of 2-ethylhexan-1-ol to Daphnia are used in the risk assessment for the parent substance. The peroxide bis(2-ethylhexyl) peroxydicarbonate hydrolyses instantly (half-life < 1 h). 2-ethylhexan-1-ol is the main degradation product of the peroxide. In the hydrolysis test it is formed at proportions of 84.4-96.6% . Therefore, the 21-d NOEC (reproduction of Daphnia) of 2-ethylhexan-1-ol of 1.6 mg/L is used in the risk assessment of bis(2-ethylhexyl) peroxydicarbonate.

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
1.6 mg/L

Additional information

The 21-day chronic toxicity of 2-ethylhexan-1-ol to Daphnia magna was studied under semi-static conditions. Daphnids were exposed to the test chemical at nominal concentrations of 150, 75, 18.75, 9.38, 4.69, 2.34 and 0 mg/L. The 21-day NOEC based on reproduction was 2.3 mg/L (nominal, corresponding to 1.6 mg/L actual). The sublethal effects were related to reproduction rate and first occurrence of offspring. Production of offspring in the treated groups indicated that 2-ethylhexan-1-ol had an effect on the reproduction at concentrations greater than 2.3 mg/L (nominal).

This study is considered as acceptable and satisfies the guideline requirements for a chronic toxicity study with freshwater invertebrates.

Results synopsis

Test type: Static renewal

NOEC: 2.3 mg/L (nominal, corresponding to an actual concentration of 1.6 mg/L)

Endpoint affected: Reproduction

As the hydrolysis experiment (see IUCLID section 5.1.2) could demonstrate, bis(2-ethylhexyl)peroxydicarbonate will not be present in the aquatic environment since hydrolysis occurs instantly and degradation products are formed. Thus, the degradation products are relevant for the toxicity that may be expected from exposure to bis(2-ethylhexyl) peroxydicarbonate. The risk assessment for bis(2-ethylhexyl)peroxydicarbonate is therefore based on data available for the major breakdown product (84.4–96.9 %) which is even more toxic compared to the other degradation products. For further details please refer to the report “Role of the degradation products of bis(2-ethylhexyl) peroxydicarbonate (EPC-S, CAS 16111-62-9) in the hazard and risk assessment” in IUCLID section 13.