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EC number: 406-176-9 | CAS number: 79072-96-1 NC-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 185 ng/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 1.85 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 18.5 ng/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 100 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- no exposure of sediment expected
Sediment (marine water)
- Hazard assessment conclusion:
- no exposure of sediment expected
Hazard for air
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- no exposure of soil expected
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
In the derivation of aquatic PNECs, the NOEC result from the algal inhibition test was used as the starting point on the basis that it is the most modern test, conducted according to modern OECD and EC test guidelines and in compliance with GLP, and the reported NOEC value was based on the analysed concentration of NC-4 in medium, rather than the nominal vaules reported in the acute fish toxicity test and the acute daphnia immobilisation test.
In each case (freshwater, salt water, and intermitten releases), the PNECaqua was calculated according to REACH Guidance Document R10 (Dose [Concentration]-Response Regarding Environment, ECHA 2008); in each case the assessment factors used were the minimum values recommended in the guidance document; 100 for fresh water, 1000 for marine water, and 10 for intermitten release. The minimum recommended factor was used on the basis that in each trophic level assessed, no harmful effects were seen at or above the limit of solubility in water; the results quoted are not effect levels, but rather the highest concentrations assessed. In addition, long-term effects are not anticipated, as the logPow of NC-4 is 1.6; as the logPow is less than 3, NC-4 is expected to have a low potential for bioaccumulation.
As recommended in the above guidance document, an assessment factor of 10 was applied to the NOEC of the sludge respiration test in the calculation of the PNECSTP.
PNECs were not calculated for the Sediment, Soil, or Oral compartments, as on consideration of the use pattern for NC-4, no release to these compartments is anticipated.
Conclusion on classification
No evidence of toxicity (mortality in the fish test, immobilisation in the Daphnia test, or respiration inhibition in the algal test) was seen for NC-4 when tested at or above the limit concentration for fish and daphnia, and above the stated water solubility level for the algal test. In retrospect, it may be noted that both the fish actute toxicity test and the acute daphnia immobilisation test were both conducted at concentrations much higher than the limit of solubility in water of NC-4, and so it may be assumed that in these tests, the concentrations to which the fish and daphnia were actually exposed were lower than those quoted.
As no toxic effects were seen for NC-4 when tested above the limit of water solubility, there is no basis on which to classify the material as Hazardous to the environment.
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