Registration Dossier
Registration Dossier
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EC number: 406-176-9 | CAS number: 79072-96-1 NC-4
Endpoint summary
Administrative data
Description of key information
Skin irritation in rabbits: Not irritating
Eye irritation in rabbits: Not irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
A skin irritation test (Huntingdon Research Centre, 1987) was conducted in 6 New Zealand White rabbits. The study was conducted according to US test guidelines. No irritation was observed in any of the animals tested.
An eye irritation test (Huntingdon Research Centre, 1987) was conducted in 6 New Zealand White rabbits. The study was conducted according to US test guidelines. Transient mild conjunctival irritation was abserved in four animals, but none of the responses were considered "positive" according to the scoring criteria used. It was concluded that instillation of NC-4 into the rabbit eye did not elicit a positive response in any of the animals tested.
Justification for classification or non-classification
Skin and eye irritation tests were conducted on NC-4, but both tests were negative for irritation. On this basis it is considered that NC-4 should not be classified as irritant to either skin or eyes.
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