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EC number: 200-002-3 | CAS number: 50-01-1
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation: aquatic / sediment
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Bioconcentration factor BCF of Guanidine was calculated using BCFBAF v3.01 EPI Suite 4.0
- GLP compliance:
- no
- Type:
- BCF
- Value:
- 3.162 other: L/kg wet-wt
- Remarks on result:
- other: regression-based method
- Type:
- BCF
- Value:
- 0.893 dimensionless
- Calculation basis:
- other: estimated log Kow used: -1.63
- Remarks on result:
- other: Arnot-Gobas method
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The calculation yielded a BCF = 0.8935 according to the Arnot-Gobas method and based on the estimated log Kow = -1.63 and BCF = 3.162 L/kg wet-wt according to the regression-based method. The result indicates a low potential for bioaccumulation.
- Executive summary:
The bioconcentration factor BCF of Guanidine was calculated using EpiWeb4.0, BCFBAFv3.01. The calculation yielded a BCF=3.162 L/kg wet-wt (regression-based) respective BCF=0.8935 (dimensionless) (Arnot-Gobas method with logKow=-1.63).
The result indicates a low potential for bioaccumulation.
The prediction is in line with the expected property, based on information of a measured Log Kow value.
Reference
Description of key information
A low potential for bioaccumulation is expected.
Key value for chemical safety assessment
- BCF (aquatic species):
- 3.2 L/kg ww
Additional information
According to the measured log Kow < -1.7 a low potential for bioaccumulation is expected.
The calculation yielded a BCF = 0.8935 according to the Arnot-Gobas method and based on the estimated log Kow = -1.63 and
BCF = 3.162 L/kg wet-wt according to the regression-based method. The result indicates a low potential for bioaccumulation.
The prediction is in line with the expected property, based on information of a measured Log Kow value.
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