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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation: aquatic / sediment
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
Qualifier:
no guideline followed
Principles of method if other than guideline:
Bioconcentration factor BCF of Guanidine was calculated using BCFBAF v3.01 EPI Suite 4.0
GLP compliance:
no
Type:
BCF
Value:
3.162 other: L/kg wet-wt
Remarks on result:
other: regression-based method
Type:
BCF
Value:
0.893 dimensionless
Calculation basis:
other: estimated log Kow used: -1.63
Remarks on result:
other: Arnot-Gobas method
Validity criteria fulfilled:
not applicable
Conclusions:
The calculation yielded a BCF = 0.8935 according to the Arnot-Gobas method and based on the estimated log Kow = -1.63 and BCF = 3.162 L/kg wet-wt according to the regression-based method. The result indicates a low potential for bioaccumulation.
Executive summary:

The bioconcentration factor BCF of Guanidine was calculated using EpiWeb4.0, BCFBAFv3.01. The calculation yielded a BCF=3.162 L/kg wet-wt (regression-based) respective BCF=0.8935 (dimensionless) (Arnot-Gobas method with logKow=-1.63).

The result indicates a low potential for bioaccumulation.

The prediction is in line with the expected property, based on information of a measured Log Kow value.

Description of key information

A low potential for bioaccumulation is expected.


Key value for chemical safety assessment

BCF (aquatic species):
3.2 L/kg ww

Additional information

According to the measured log Kow < -1.7 a low potential for bioaccumulation is expected.

The calculation yielded a BCF = 0.8935 according to the Arnot-Gobas method and based on the estimated log Kow = -1.63 and

BCF = 3.162 L/kg wet-wt according to the regression-based method. The result indicates a low potential for bioaccumulation.

The prediction is in line with the expected property, based on information of a measured Log Kow value.