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EC number: 200-002-3
CAS number: 50-01-1
Guanidine hydrochloride was evaluated to be inherently biodegradable.
There are 3 acute tests (fish, daphnia, algae) and 2 chronic tests
(fish, daphnia) with freshwater organisms available, the lowest obtained
chronic value is the NOEC of 2.9 mg/L for Daphnia magna. Terrestrial
toxicity data are available for plants and soil microorganisms (both
acute and chronic), the lowest available value is the NOEC = 435 mg/Kg
soil ww for terrestrial plants.
Short-term toxicity to aquatic organisms:
Fish: LC50 (96 h) = 690 mg/L a.i. for Pimephales promelas (test with
read-across substance Guanidine nitrate).
Invertebrates: EC50 (48h) = 70.2 mg/L for Daphnia magna (test with
read-across substance Guanidine nitrate, similar to OECD 202). Algae and
cyanobacteria: ErC50 (72 h) = 33.5 mg/L for Pseudokirchneriella
subcapitata (test with read-across substance Guanidine nitrate,
according to EU C.3)
Long-term toxicity to aquatic organisms:
Fish: NOEC = 181 mg/L for Fathead minnow (test with read-across
substance Guanidine nitrate, similar to OECD 210). Invertebrates: NOEC =
2.9 mg/L for Daphnia magna (test with read-across substance Guanidine
nitrate, similar to OECD 211).
Biodegradation in water:
In a study similar to OECD 301, readily biodegradation was shown.
However, bacteria naturally occurring in river water were used,
downstream a guanidine emitting site, and thus the inoculum is expected
to be adapted. For this reason, the substance is classified as
inherently instead of readily biodegradable.
Based on the log Kow below 0, the substance will have a low potential
for bioaccumulation in aquatic organisms and a low potential for
adsorption to organic matter of soils and sediments at environmental
relevant pH values. Based on the available information, there is no
indication of a bioaccumulation potential in organisms and, hence,
secondary poisoning is not considered as relevant.
Toxicity to terrestrial plants: NOEC = 435 mg/Kg soil ww; wheat
germination, seeding groth (test with read-across substance Guanidine
nitrate, similar to OECD 210). The test is regarded to cover acute
effects and can be used as estimate of chronic toxicity following ECHA
Guidance Chapter R.7c (2008). (Remark: key value for chemical safety
assessment NOEC 435 mg/kg is wet weight; pick list doesn't allow to
choose ww but dw)
Toxicity to terrestrial microorganisms:
NOEC = 636 mg/Kg soil ww; natural soil microorganism (test with
read-across substance Guanidine nitrate, similar to OECD 210). (Remark:
key value for chemical safety assessment NOEC 636 mg/kg is wet weight;
pick list doesn't allow to choose ww but dw)
According to experimental results, Guanidine chloride is inherently
biodegradable. Acute and chronic results for species for all 3 tropic
levels are above 1 mg/l. Following these findings an environmental
classification according to current CLP legislation, EU GHS (Regulation
(EC) No 1272/2008, 3. ATP) is not necessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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