Registration Dossier
Registration Dossier
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EC number: 271-138-9 | CAS number: 68516-20-1 A complex combination of hydrocarbons produced by the distillation of products from a steam-cracking process. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C7 through C12 and boiling in the range of approximately 130°C to 220°C(266°F to 428°F).
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This summary has a reliability of 2 because the results are estimated using a computer model that is appropriate for use with this petroleum substance.
- Justification for type of information:
- Petrotox is a well documented and peer reviewed model that is widely used across the petrochemicals industry. This substance fits within the criteria of the model and there are no reservations about the validity of the model runs. It is expected that this data is reliable with restrictions.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The aquatic toxicity was estimated by a QSAR, the PETROTOX computer model (version 3_06). This model combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. PETROTOX computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
- GLP compliance:
- no
- Remarks:
- The data were calculated by a computer model
- Analytical monitoring:
- not required
- Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Test type:
- other: QSAR modelled data
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LL50
- Effect conc.:
- 1.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: QSAR calculation
- Conclusions:
- The estimated 96-hr LL50 value for Onchorhynchus mykiss, is 1.1 mg/L.
- Executive summary:
The aquatic toxicity was estimated using the PETROTOX computer model, which combines a partitioning model (used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading) with the Target Lipid Model (used to calculate acute and chronic toxicity of non-polar narcotic chemicals). PETROTOX computes toxicity based on the summation of the aqueous phase concentrations of hydrocarbon block(s) that represent a petroleum substance and membrane water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
The estimated 96-hr LL50 value for Onchorhynchus mykiss, is 1.1 mg/L.
Reference
Description of key information
The aquatic toxicity was estimated using the PETROTOX computer model, which combines a partitioning model (used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading) with the Target Lipid Model (used to calculate acute and chronic toxicity of non-polar narcotic chemicals). PETROTOX computes toxicity based on the summation of the aqueous phase concentrations of hydrocarbon block(s) that represent a petroleum substance and membrane water partition coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
The estimated 96-hr LL50 value for Onchorhynchus mykiss, is 1.1 mg/L.
Supporting data on Toluene and Ethylbenzene, two constituents in Category J were used to support the QSAR prediction. Experiemental 96 -hour LC50s of 5.5 and 8.4 mg/L (for toluene and ethylbenzene, respectively) have been reported.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.1 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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