Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
271-138-9
CAS no.:
68516-20-1
Index number:
649-367-00-4
Molecular formula:
SMILES:
InChI:
Type of substance:
UVCB
Origin:
Petroleum product
Registered compositions:
24
Of which contain:
5 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance may be fatal if swallowed and enters airways, may cause genetic defects and may cause cancer.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is fatal if inhaled, is very toxic to aquatic life with long lasting effects, causes damage to organs through prolonged or repeated exposure, is toxic in contact with skin, is toxic if swallowed, is very toxic to aquatic life, is suspected of damaging fertility or the unborn child, causes serious eye irritation, is an extremely flammable liquid and vapour, is suspected of causing cancer, may cause respiratory irritation, causes skin irritation, may cause an allergic skin reaction and may cause drowsiness or dizziness.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is toxic to aquatic life with long lasting effects and is a highly flammable liquid and vapour.

Breakdown of all 214 C&L notifications submitted to ECHA

Asp. Tox. 1 H304 Harmonised Classification
Muta. 1B H340 Harmonised Classification
Carc. 1B H350 Harmonised Classification
Repr. 2 H361
Eye Irrit. 2 H319
Aquatic Chronic 2 H411
STOT RE 1 H372
Skin Irrit. 2 H315
STOT SE 3 H336
Flam. Liq. 2 H225
STOT SE 3 H335
Acute Tox. 4 H312
Acute Tox. 4 H302
Aquatic Acute 1 H400
Aquatic Chronic 1 H410
https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/more.png 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • C
Officially recognised in the EU as Carcinogenic (Harmonised C&L).
  • C
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Carcinogenic (22.03% of REACH registrations).
  • M
Officially recognised in the EU as Mutagenic (Harmonised C&L).
  • M
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Mutagenic (22.03% of REACH registrations).
  • Ss
There is no overall agreement among data submitters, but a minority indicate they consider this substance as Skin sensitising (27.12% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 9 active registrations under REACH, 2 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 000 to < 10 000 000 tonnes per annum.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: fuels.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and in materials as fuel sources, with limited exposure to unburned product to be expected.

Other release to the environment of this substance is likely to occur from: indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, manufacturing of the substance, formulation in materials, in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following areas: formulation of mixtures and/or re-packaging. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: as an intermediate step in further manufacturing of another substance (use of intermediates), of substances in closed systems with minimal release, in processing aids at industrial sites, manufacturing of the substance and for thermoplastic manufacture.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure, closed batch processing in synthesis or formulation, laboratory work and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites, formulation of mixtures, formulation in materials, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates), as processing aid, for thermoplastic manufacture, as processing aid and of substances in closed systems with minimal release.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

Prevention statements

When handling this substance: do not handle until all safety precautions have been read and understood; take actions to prevent static discharges; do not breathe the dust, fume, gas, mist, vapours or spray; contaminated work clothing should not be allowed out of the workplace; keep away from heat, sparks, open flames and/or hot surfaces – No smoking; use only outdoors or in a well-ventilated area; obtain special instructions before use; do not eat, drink or smoke when using this product; avoid release to the environment; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier; avoid breathing the dust, fume, gas, mist, vapours or spray.

Response statements

In case of incident: Wash contaminated clothing before reuse. Get medical advice/attention if you feel unwell. If swallowed: immediately call a poison center or doctor/physician. If exposed or concerned: get medical advice/attention. If skin irritation occurs: Get medical advice/attention. If on skin (or hair): take off immediately all contaminated clothing. Rinse skin with water or shower. If inhaled: remove victim to fresh air and keep at rest in a position comfortable for breathing. Collect spillage. If swallowed: rinse mouth. Do not induce vomiting. If inhaled: call a poison center or doctor/physician if you feel unwell. If in eyes: rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do – continue rinsing. Rinse the mouth. Do not induce vomiting. If eye irritation persists get medical advice/attention. Follow specific treatment (see label). If swallowed: call a poison center or doctor/physician if you feel unwell. If on skin: wash with soap and water.

Storage statements

Store this substance in a dry place; locked up; in a well-ventilated place and keeping container tightly closed.

Disposal statements

The substance must be disposed in accordance with local/regional/national/international regulation.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Braskem Netherlands B.V., Weena 00240, C 9th floor NL - 3012 NJ PO Box 30128 3001 DC Rotterdam Netherlands
  • DOW BENELUX B.V., Postbus 48 4530 AA Terneuzen Netherlands
  • Glencore International Import BV, Prinses Beatrixlaan 582 2595 BM Den Haag Netherlands
  • INEOS Manufacturing Deutschland GmbH, Alte Strasse 201 50769 Koeln Germany
  • Koole Tankstorage Botlek B.V., Oude Maasweg 6 3197 KJ Rotterdam Netherlands
  • Rain Carbon Germany GmbH, Kekulestr. 30 44579 Castrop-Rauxel Germany
  • Repsol Petroleo, S.A., Calle Mendez Alvaro, 44 28045 Madrid Madrid Spain
  • SABIC Petrochemicals B.V., Europaboulevard 1 6135 LD Sittard Limburg Netherlands
  • versalis S.p.A., P.zza Boldrini 1 20097 San Donato Milanese MILANO Italy
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • OLTCHIM SA, Uzinei 1 240050 Ramnicu Valcea Valcea Romania
  • RÜTGERS Basic Aromatics GmbH, Kekulestr. 30 44579 Castrop-Rauxel Germany
  • SABIC UK Petrochemicals Limited, Wilton Centre TS10 4RF Redcar Cleveland United Kingdom
  • Total Olefins Antwerp, Scheldelaan 10 2030 Antwerpen Belgium
  • Total Petrochemicals France SA, Immeuble Le Linéa 1, rue du Général Leclerc 92047 Paris La Défence Cedex France

Substance names and other identifiers

[A complex combination of hydrocarbons produced by the distillation of products from a steam-cracking process. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C7 through C12 and boiling in the range of approximately 130°C to 220°C (266°F to 428°F).]
A complex combination of hydrocarbons produced by the distillation of products from a steam-cracking process. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C7 through C12 and boiling in the range of approximately 130°C to 220°C(266°F to 428°F).
C&L Inventory
Low boiling point naphtha - unspecified
A complex combination of hydrocarbons produced by the distillation of products from a steam-cracking process. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C7 through C12 and boiling in the range of approximately 130°C to 220°C(266°F to 428°F).
C&L Inventory
Medium steam cracked aromatic naphtha (petroleum)
A complex combination of hydrocarbons produced by the distillation of products from a steam-cracking process. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C7 through C12 and boiling in the range of approximately 130°C to 220°C(266°F to 428°F).
Other
Naphtha (petroleum), steam-cracked middle arom.
EC Inventory, REACH pre-registration, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances
Naphtha (petroleum), steam-cracked middle arom.
A complex combination of hydrocarbons produced by the distillation of products from a steam-cracking process. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C7 through C12 and boiling in the range of approximately 130°C to 220°C(266°F to 428°F).
C&L Inventory, REACH pre-registration, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances
Naphtha (petroleum), steam-cracked middle arom.; Low boiling point naphtha -unspecified [ complex combination of hydrocarbons produced by the distillation of products from a steam-cracking process. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C7 through C12 and boiling in the range of approximately 130o C to 220o C (266°F to 428°F).]
A complex combination of hydrocarbons produced by the distillation of products from a steam-cracking process. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C7 through C12 and boiling in the range of approximately 130°C to 220°C(266°F to 428°F).
CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, General Product Safety Directive - Hazardous Substances, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
Naphtha (petroleum), steam-cracked middle arom.; Low boiling point naphtha -unspecified
A complex combination of hydrocarbons produced by the distillation of products from a steam-cracking process. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C7 through C12 and boiling in the range of approximately 130°C to 220°C(266°F to 428°F).
FCM Active and Intelligent Materials - CMRs not allowed for use, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Workplace Signs - minimum requirements & signs on containers and pipes, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes
Naphtha, petroleum, steam-cracked middle arom.
A complex combination of hydrocarbons produced by the distillation of products from a steam-cracking process. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C7 through C12 and boiling in the range of approximately 130°C to 220°C(266°F to 428°F).
Other
(Keerulise koostisega süsivesinike segu, mis tekib aurufaasilise krakkimise produktide destillatsioonil. Koosneb peamiselt aromaatsetest süsivesinikest, mille süsiniku aatomite arv on valdavalt vahemikus C7 kuni C12, ning on keemistemperatuuriga umbes 130°C kuni 220 °C.) (et)
C&L Inventory
(Složeni sastav ugljikovodika proizveden destilacijom proizvoda iz postupka parnog krekiranja. Sastoji se pretežito od aromatskih ugljikovodika koji imaju broj ugljikovih atoma pretežito u području od C7 do C12 i vriju u području približno od 130 °C do 220 °C.) (hr)
C&L Inventory
[Kompleks blanding av hydrokarboner dannet ved destillasjon av produkter fra dampkrakking. Består for det meste av aromatiske hydrokarboner, hovedsakelig C7 til C12, med omtrentlig kokepunktsintervall fra 130 °C til 220 °C (266 °F til 428 °F).] (no)
C&L Inventory
[Kompleksna kombinacija ogljikovodikov pridobljena z destilacijo proizvodov iz parnega kreking procesa. Sestoji pretežno iz aromatskih ogljikovodikov s številom ogljikovih atomov pretežno v območju med C7 in C12 ter z vreliščem v območju približno med 130 °C in 220 °C.] (sl)
C&L Inventory
[komplexe Kombination von Kohlenwasserstoffen, hergestellt durch Destillation von Produkten aus dem Dampfkracken; besteht vorwiegend aus aromatischen Kohlenwasserstoffen mit Kohlenstoffzahlen überwiegend im Bereich von C7 bis C12 mit einem Siedebereich von etwa 130 °C bis 220 °C] (de)
C&L Inventory
[Komplexná zmes uhľovodíkov získavaná destiláciou produktov z procesu parného krakovania. Pozostáva predovšetkým z aromatických uhľovodíkov s počtom atómov uhlíka prevažne v rozmedzí od C7 do C12. Má teplotu varu v rozmedzí približne od 130 °C do 220 °C.] (sk)
C&L Inventory
[O combinaţie complexă de hidrocarburi produsă prin distilarea produşilor de cracare cu vapori. Constă cu precădere în hidrocarburi aromatice al căror număr de atomi de carbon variază între C7 şi C12 şi al căror punct de fierbere este cuprins între 130°C şi 220°C (266°F şi 428°F).] (ro)
C&L Inventory
[Ogļūdeņražu savienojumu komplekss, kas iegūts, destilējot tvaika krekinga procesa produktus. Sastāv pārsvarā no aromātiskiem ogļūdeņražiem ar oglekļa atomu skaitu pārsvarā no C7 līdz C12, aptuvenā viršanas temperatūra no 130°C līdz 220°C (266°F līdz 428°F).] (lv)
C&L Inventory
[Složitá směs uhlovodíků získaná destilací produktů z pyrolýzy. Je složena převážně z aromatických uhlovodíků s počtem uhlíkových atomů převážně v rozmezí C7 až C12 a s rozmezím teplot varu přibližně 130 °C až 220 °C.] (cs)
C&L Inventory
[Sudėtinis angliavandenilių mišinys, gaunamas distiliuojant krekingo vandens garais produktus. Jį sudaro daugiausia aromatiniai angliavandeniliai, turintys anglies atomų skaičių daugiausia nuo C7 iki C12, ir kurių virimo temperatūra maždaug nuo 130 °C iki 220 °C (nuo 266 °F iki 428 °F).] (lt)
C&L Inventory
[Szénhidrogének komplex elegye, melyet gőzkrakkolási folyamat termékeinek desztillációjával nyernek. Főleg aromás szénhidrogénekből áll, melyek szénatomszáma főleg a C7-C12 tartományban van, forrásponttartománya nagyjából 130°C-tól 220°C-ig (266°F-től 428°F-ig) terjed.] (hu)
C&L Inventory
[Πολύπλοκος συνδυασμός υδρογονανθράκων που παράγεται με απόσταξη προϊόντων ατμοπυρόλυσης. Συνίσταται κυρίως από αρωματικούς υδρογονάνθρακες με αριθμό ατόμων άνθρακα κυρίως μεταξύ C7 και C12 που αποστάζουν μεταξύ 130 °C και 220 °C περίπου.] (el)
C&L Inventory
[Комплексна комбинация от въглеводороди, получена при дестилацията на продукти от инсталация за паров крекинг. Състои се основно от въглеводороди с брой на въглеродните атоми преобладаващо в интервала от C7 до C12 включително и с температура на кипене приблизително в интервала от 130°C до 220°C (266°F до 428°F).] (bg)
C&L Inventory
Alacsony forráspontú benzin – nem meghatározott (hu)
C&L Inventory
Benzin (nafta), parom krekiran srednje arom. (hr)
C&L Inventory
Benzin (nyersolaj), gőzkrakkolt aromás középfrakció (hu)
C&L Inventory
Benzyna (ropa naftowa), średnie aromaty z krakingu parowego (pl)
C&L Inventory
Benzínová frakce (ropná), pyrolyzní střední aromatická (cs)
C&L Inventory
combinación compleja de hidrocarburos producida por la destilación de productos de un proceso de craqueo a vapor; compuesta fundamentalmente de hidrocarburos aromáticos con un número de carbonos en su mayor parte dentro del intervalo de C7 a C12 y con un intervalo de ebullición aproximado de 130 °C a 220 °C (es)
C&L Inventory
Combinaison complexe d'hydrocarbures obtenue par distillation des produits résultant d'un vapocraquage. Se compose principalement d'hydrocarbures aromatiques dont le nombre de carbones se situe en majorité dans la gamme C7-C12 et dont le point d'ébullition est compris approximativement entre 130°C et 220°C. (fr)
C&L Inventory
Combinazione complessa di idrocarburi ottenuta per distillazione di prodotti provenienti da un processo di steam cracking. È costituita in prevalenza da idrocarburi aromatici con numero di atomi di carbonio prevalentemente nell'intervallo C7-12 e punto di ebollizione nell'intervallo 130 °C - 220 °C ca. (da 266°F a 428°F). (it)
C&L Inventory
Combinação complexa de hidrocarbonetos obtida por destilação de produtos de um processo de steam cracking. É constituída predominantemente por hidrocarbonetos aromáticos com número de átomos de carbono predominantemente na gama C7 a C12 e destilação no intervalo aproximado de 130 °C a 220 °C. (pt)
C&L Inventory
Een complexe verzameling koolwaterstoffen, verkregen door destillatie van producten uit een stoomkraakproces. Bestaat voornamelijk uit aromatische koolwaterstoffen, overwegend C7 tot en met C12, met een kooktraject van ongeveer 130°C tot 220°C. (nl)
C&L Inventory
En sammensat blanding af carbonhydrider fremstillet ved destillationen af produkterne fra en dampkrakningsproces. Den består overvejende af aromatiske carbonhydrider, overvejende C7 til og med C12, med kogeinterval omtrent fra 130 °C til 220 °C (266 ºF til 428 ºF). (da)
C&L Inventory
Fracţia nafta (petrol), vaporizare cracare mediu aromatică (mt)
C&L Inventory
Fracţia nafta (petrol), vaporizare cracare mediu aromatică (ro)
C&L Inventory
Fracţia nafta cu punct de fierbere la temperaturi scăzute - nespecificat (mt)
C&L Inventory
Fracţia nafta cu punct de fierbere la temperaturi scăzute - nespecificat (ro)
C&L Inventory
Komplex blandning av kolväten, erhållen genom destillation av produkter från ångkrackning. Består främst av aromatiska kolväten, i synnerhet C7 till C12, med ungefärligt kokpunktsintervall från 130 °C till 220 °C. (sv)
C&L Inventory
Lavtkogende uspecificeret nafta (da)
C&L Inventory
lavtkokende nafta - uspesifisert (no)
C&L Inventory
Ligroīns (nafta), tvaika krekings, vidējais, arom. (lv)
C&L Inventory
Ligroīns ar zemu viršanas temperatūru – nestandarta (lv)
C&L Inventory
Lågkokande nafta – ospecificerad (sv)
C&L Inventory
Madala keemispunktiga raskbensiin – määratlemata (et)
C&L Inventory
Matalalla kiehuva teollisuusbensiini – täsmentämätön (fi)
C&L Inventory
Monimutkainen seos hiilivetyjä, saatu tislaamalla tuotteita höyrykrakkausprosessista. Koostuu pääasiassa aromaattisista hiilivedyistä, joiden hiililuvut ovat pääasiassa välillä C7:stä C12:een ja jotka kiehuvat likimäärin välillä 130°C:sta 220 °C:een (266°F:sta 428°F:iin). (fi)
C&L Inventory
Nafta (aardolie), stoomgekraakte aromatische middenfracties (nl)
C&L Inventory
nafta (petroleum), dampkrakket middels tung aromatisk (no)
C&L Inventory
Nafta (petroleum), ångkrackad medeltung aromatisk (sv)
C&L Inventory
nafta (petrolio), tagli aromatici medi di steam cracking (it)
C&L Inventory
nafta (petróleo), fracción aromática intermedia craqueada a vapor (es)
C&L Inventory
Nafta (petróleo), fracção aromática intermédia de steam cracking (pt)
C&L Inventory
nafta (zemeljsko olje), parno krekirana aromatska srednja frakcija (sl)
C&L Inventory
nafta con basso punto di ebollizione - non specificata (it)
C&L Inventory
Nafta de baixo ponto de ebulição - não especificada (pt)
C&L Inventory
nafta de bajo punto de ebullición, sin especificar (es)
C&L Inventory
Nafta met laag kookpunt - niet gespecifieerd (nl)
C&L Inventory
Naphta moyen aromatique (pétrole), vapocraquage;naphta à bas point d'ébullition — non spécifié;[Combinaison complexe d'hydrocarbures obtenue par distillation des produits résultant d'un vapocraquage. Se compose principalement d'hydrocarbures comportant majoritairement entre 7 et 12 atomes de carbone (C7-C12) et dont l'intervalle d'ébullition est compris approximativement entre 130 et 220 oC (entre 266 et 428o F).] (fr)
C&L Inventory
naphta à point d'ébullition bas - non spécifié (fr)
C&L Inventory
Naphtha (Erdöl), dampfgekrackte mittlere aromatische Fraktion (de)
C&L Inventory
naphtha (råolie), dampkrakket middeltung aromatisk (da)
C&L Inventory
Naphtha, niedrigsiedend, nicht spezifiziert (de)
C&L Inventory
naspecificirana nafta z nizko temperaturo vrelišča (sl)
C&L Inventory
Nisko-vrijući benzin - nespecificiran (hr)
C&L Inventory
Niskowrząca benzyna - niespecyfikowana (pl)
C&L Inventory
Nízkovroucí benzínová frakce – nespecifikovaná (cs)
C&L Inventory
O combinaţie complexă de hidrocarburi produsă prin distilarea produşilor de cracare cu vapori. Constă cu precădere în hidrocarburi aromatice al căror număr de atomi de carbon variază între C7 şi C12 şi al căror punct de fierbere este cuprins între 130°C şi 220°C (266°F şi 428°F). (mt)
C&L Inventory
Pirminis benzinas (nafta), krekingo vandens garais, vidurinioji aromatinių junginių frakcija (lt)
C&L Inventory
Raskbensiin (nafta), aurkrakitud keskmine aromaatne (et)
C&L Inventory
Teollisuusbensiini (maaöljy), höyrykrakattu keskiaromaattinen (fi)
C&L Inventory
Złożona mieszanina węglowodorów otrzymywana podczas destylacji produktów z krakingu z parą wodną. Składa się przede wszystkim z węglowodorów aromatycznych o liczbie atomów węgla głównie w zakresie od C7 do C12 wrzących w zakresie temp. od ok. 130°C do 220°C (pl)
C&L Inventory
ťažký benzín (ropný), z parného krakovania, stredná aromatická frakcia (sk)
C&L Inventory
ťažký benzín s nízkou teplotou varu - nešpecifikovaný (sk)
C&L Inventory
Žematemperatūris pirminis benzinas – neapibrėžtas (lt)
C&L Inventory
Νάφθα χαμηλού σημείου ζέσεως - μη προσδιοριζόμενη (el)
C&L Inventory
νάφθαΝάφθα (πετρελαίου), μεσαίο κλάσμα αρωματικών ενώσεων, ατμοπυρολυμένη (el)
C&L Inventory
Нискооктанов бензин (нефт), от паров крекинг, средни ароматни (bg)
C&L Inventory
Нискооктанов бензин с ниска температура на кипене-неспецифициран (bg)
C&L Inventory
Naphtha (petroleum), steam-cracked middle arom.
Other
Blend 88
Registration dossier
Naphtha (petroleum), steam-cracked middle arom.
C&L Inventory, Registration dossier
Naphtha (petroleum), steam-cracked middle arom.
Registration dossier
AB9 Solvent
Registration dossier
Aromatic C9
Registration dossier
Blend TN-160, Blend TN-120
Registration dossier
Blendstock
Registration dossier
Btx
Registration dossier
Essence brute
Registration dossier
Essence resinifiable Totale
Registration dossier
Harzöl I
Registration dossier
HF 1800
Registration dossier
High Benzene Naphthas
Registration dossier
Hydrocarbon Resin
Registration dossier
Hydrotreated Gasoline C8-C9 Cut
Registration dossier
Light oil
Registration dossier
Novaboost
Registration dossier
Premium Octane Pyrolysis Gasoline
Registration dossier
Resin Oil I (Harzöl I)
Registration dossier
Solvent C9
Registration dossier
Solvent Naphtha VE
Registration dossier
Superblend
Registration dossier
TN160
Registration dossier
TX Cut
Registration dossier
Unilene Resin
Registration dossier
649-367-00-4
Index number
C&L Inventory
68516-20-1
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, FCM Active and Intelligent Materials - CMRs not allowed for use, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Carc and Muta Directive, Annex I - Substances, Mixtures & Processes, Physical, Biological and Chemical Agents & Processes and Work

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 31 studies submitted
  • 30 studies processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [30]
C Form
Other (92%), Viscous (8%) [13]
C Odour
Characteristic of aromatic compounds (71%), Other (21%) [28]
C Substance type
Petroleum product (68%), Organic (32%) [28]

Type of Study provided
Studies with data
Key study 13 17
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 7 summaries submitted
  • 6 summaries processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 12 studies submitted
  • 11 studies processed
R Melting / freezing point
-100 - -29 °C @ 101.3 kPa [13]

Type of Study provided
Studies with data
Key study 11
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 7 summaries submitted
  • 6 summaries processed
Melting / freezing point at 101 325 Pa
-95.15 - 32.2 °C

Boiling point

Study results
  • 28 studies submitted
  • 20 studies processed
R Boiling point
25 - 265 °C @ 100.7 - 101.33 kPa [22]

Type of Study provided
Studies with data
Key study 16 5
Supporting study 1 6
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 7 summaries submitted
  • 6 summaries processed
Boiling point at 101 325 Pa
80.09 - 172.2 °C

Density

Study results
  • 18 studies submitted
  • 8 studies processed
R Relative density
0.69 - 0.89 @ 20 °C [8]

Type of Study provided
Studies with data
Key study 11
Supporting study 1 6
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 7 summaries submitted
  • 6 summaries processed
Relative density at 20°C
0.87 - 866

Vapour pressure

Study results
  • 36 studies submitted
  • 27 studies processed
R Vapour pressure
2.5 - 584.84 hPa @ 20 - 50 °C [39]

Type of Study provided
Studies with data
Key study 28
Supporting study 3 5
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 7 summaries submitted
  • 6 summaries processed
Vapour pressure
1.86 - 111.4 hPa @ 20 - 21.1 °C

Partition coefficient

Study results
  • 12 studies submitted
  • 10 studies processed
R Log Pow
2.2 - 6.5 @ -248.15 - 25 °C and pH 6.2 - 7 [10]

Type of Study provided
Studies with data
Key study 10
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 7 summaries submitted
  • 6 summaries processed
Log Kow (Log Pow)
2.13 - 6.5 @ 20 °C

Water solubility

Study results
  • 10 studies submitted
  • 8 studies processed
R Water solubility (mass/vol.)
25 - 600 mg/L @ 20 °C and pH 5.2 - 9.1 [7]
R Water solubility (vol%)
0.1 - 0.7 vol% @ 20 °C and pH 6.4 [2]

Type of Study provided
Studies with data
Key study 8
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 7 summaries submitted
  • 6 summaries processed
Water solubility
20 - 1 880 mg/L @ 20 - 25 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 9 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 9
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Surface tension at 20 °C
71.1 - 71.8 mN/m @ 243 - 244 mg/L

Flash point

Study results
  • 14 studies submitted
  • 14 studies processed
R Flash point
-30 - 107 °C @ 101.3 kPa [16]

Type of Study provided
Studies with data
Key study 14
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Flash point at 101 325 Pa
7.4 - 73 °C

Auto flammability

Study results
  • 9 studies submitted
  • 9 studies processed
R Autoflammability / self-ignition
328 - 502 °C @ 99.5 - 101.3 kPa [9]

Type of Study provided
Studies with data
Key study 9
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Autoflammability / self-ignition at 101 325 Pa
421 - 429 °C

Flammability

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Explosiveness

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Viscosity

Study results
  • 14 studies submitted
  • 11 studies processed
R dynamic viscosity (in mPa s)
0.32 - 0.95 [16]
R kinematic viscosity (in mm²/s)
0.47 - 1.9 [21]

Type of Study provided
Studies with data
Key study 11
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Static viscosity at 20 °C
3.25 mm²/s
Dynamic viscosity at 20 °C
0.723 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 5 studies submitted
  • 1 study processed
C Interpretation of results
Not readily biodegradable (100%) [1]

Type of Study provided
Studies with data
Key study 3 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 5 summaries submitted
  • 5 summaries processed
Biodegradation in water
Under test conditions no biodegradation observed (80%), Readily biodegradable (20%)

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Bioaccumulation: aquatic / sediment

Study results
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 2 summaries processed
Bioaccumulation Factor (BCF) - L/kg ww
150.1 L/kg ww
Bioaccumulation Factor (BCF) - dimensionless
1 112

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 3
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
Koc at 20°C
3.04

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 3 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater No data available: testing technically not feasible (2)
Intermittent releases (freshwater) No data available: testing technically not feasible (2)
Marine water No data available: testing technically not feasible (2)
Intermittent releases (marine water) No data available: testing technically not feasible (2)
Sewage treatment plant (STP) No data available: testing technically not feasible (2)
Sediment (freshwater) No data available: testing technically not feasible (2)
Sediment (marine water) No data available: testing technically not feasible (2)
Hazard for Air
Air Hazard related to composition of atmosphere identified (2)
Hazard for Terrestrial Organism
Soil No data available: testing technically not feasible (2)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (2)

Short–term toxicity to fish

Study results
  • 6 studies submitted
  • 3 studies processed
P/RResults
LC50 (4 days) 1 - 8.41 mg/L [2]
LL50 (4 days) 1.1 mg/L [2]

Type of Study provided
Studies with data
Key study 2 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Short–term toxicity to aquatic invertebrates

Study results
  • 7 studies submitted
  • 4 studies processed
P/RResults
EC50 (48 h) 1.2 - 4.7 mg/L [3]
LL50 (48 h) 1.99 mg/L [1]
EL50 (48 h) 1.2 - 3.3 mg/L [2]

Type of Study provided
Studies with data
Key study 3 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 3 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to aquatic algae and cyanobacteria

Study results
  • 6 studies submitted
  • 4 studies processed
P/RResults
EC50 (4 days) 910 - 18 400 µg/L [6]
EC50 (72 h) 1.3 - 18.9 mg/L [4]
NOEC (4 days) 120 - 7 840 µg/L [3]
NOEC (72 h) 6.47 mg/L [2]
EL50 (4 days) 1.2 - 2.2 mg/L [4]

Type of Study provided
Studies with data
Key study 3 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
EC50 for freshwater algae
790 µg/L

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
NOEC (5 days) 2 mg/L [1]

Type of Study provided
Studies with data
Key study 1 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 3 summaries submitted
  • 1 summary processed
EC50 for microorganisms
28.99 mg/L

Sediment toxicity

Study results
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 4
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 6
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 6
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 6 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 6
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to soil microorganisms

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 7 summaries submitted
  • 7 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 2.31 mg/m³ repeated dose toxicity
Acute /short term: (DNEL) 384 mg/m³ neurotoxicity
Local Effects
Long-term: (DNEL) 2.31 mg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 160.23 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 950 µg/kg bw/day repeated dose toxicity
Acute /short term: High hazard (no threshold derived)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 690 µg/m³ repeated dose toxicity
Acute /short term: (DNEL) 226 mg/m³ neurotoxicity
Local Effects
Long-term: (DNEL) 690 µg/m³ irritation (respiratory tract)
Acute /short term: (DNEL) 143.5 mg/m³ irritation (respiratory tract)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 280 µg/kg bw/day repeated dose toxicity
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
Local Effects
Long-term: Low hazard (no threshold derived)
Acute /short term: Low hazard (no threshold derived)
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 30 µg/kg bw/day repeated dose toxicity
Acute /short term: (DNEL) 25.6 mg/kg bw/day acute toxicity
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 29 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study 5 1
Supporting study 12 4
Weight of evidence
Other 4
Data waiving
Not feasible
Sci. unjustified 3
Exposure cons.
Other
Study data: dermal absorption
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study 1
Supporting study 6 5
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
M/C Summaries
  • 6 summaries submitted
  • 6 summaries processed
Bioaccumulation potential:
Low bioaccumulation potential
Absorption values
Oral: 100 %
Dermal: 3.6 %
Inhalation: 50 %

Acute toxicity

Study results
oral
  • 15 studies submitted
  • 14 studies processed
P/RResults
LD50 512 - 6 631 mg/kg bw (rat) [16]
LD50 5 251 - 5 627 mg/kg bw (mouse) [4]
M/CInterpretations of results
Practically nontoxic [1]

Type of Study provided
oral
Studies with data
Key study 14
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 17 studies submitted
  • 16 studies processed
P/RResults
LC50 (6 h) 1.723 mg/L air (rat) [1]
LC50 (6 h) 284 - 353 ppm (rat) [2]
LC50 (4 h) 5.14 - 43.767 mg/L air (rat) [16]
LC50 (4 h) 5 922 - 13 700 ppm (rat) [11]
LC50 (6 h) 738.5 mg/m³ air (mouse) [1]
M/CInterpretations of results
Toxic [2]

inhalation
Studies with data
Key study 14 2
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 13 studies submitted
  • 12 studies processed
P/RResults
LD50 2 000 mg/kg bw (rat) [1]
LD50 2 000 - 12 126 mg/kg bw (rabbit) [8]
LD50 5 000 mL/kg bw (rabbit) [2]
M/CInterpretations of results
Practically nontoxic [2]

dermal
Studies with data
Key study 10
Supporting study 1
Weight of evidence 2
Other
Data waiving
no waivers
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 7 summaries submitted
  • 6 summaries processed
Oral route:
Adverse effect observed LD50 590 mg/kg bw
Inhalation route:
Adverse effect observed LC50 1 972 mg/m³
Dermal route:
No adverse effect observed LD50 2 000 mg/kg bw

Irritation / corrosion

Study results
Study data: skin
  • 17 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 6 6
Supporting study 1
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: eye
  • 16 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 6 1
Supporting study 1
Weight of evidence 3 3
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
M/C Summaries
  • 7 summaries submitted
  • 6 summaries processed
Skin
Adverse effect observed (irritating)
Eye
Adverse effect observed (irritating)
Respiratory
Adverse effect observed (irritating)

Sensitisation

Study results
Study data: skin
  • 12 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 7
Supporting study 1
Weight of evidence 2
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other 1
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 7 summaries submitted
  • 6 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 24 studies submitted
  • 15 studies processed
P/RResults
NOAEL (rat): 4 - 625 mg/kg bw/day [16]
NOAEL (mouse): 625 mg/kg bw/day [2]
LOAEL (rat): 25 - 1 250 mg/kg bw/day [7]
LOAEL (mouse): 1 250 mg/kg bw/day [2]

Type of Study provided
Study data: oral
Studies with data
Key study 12 3
Supporting study 3
Weight of evidence
Other 4
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: inhalation
  • 24 studies submitted
  • 22 studies processed
P/RResults
NOAEC (rat): 96 - 2 355 mg/m³ air [7]
NOAEC (rat): 30 - 7 000 ppm [23]
NOAEC (mouse): 32 - 96 mg/m³ air [2]
NOAEC (mouse): 5 - 2 000 ppm [5]
LOAEC (rat): 2.261 - 4.71 mg/L air [5]

Study data: inhalation
Studies with data
Key study 18 4
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 2
Study data: dermal
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 3
M/C Summaries
  • 7 summaries submitted
  • 6 summaries processed
Oral route - systemic effects:
Adverse effect observed NOAEL 4 mg/kg bw/day (subacute, rat)
Dermal route - systemic effects:
No adverse effect observed NOAEL 2 000 mg/kg bw/day (subacute, rabbit)
Dermal route - local effects:
Adverse effect observed LOAEL 200 mg/cm² (subacute, rabbit)
Inhalation route - systemic effects:
Adverse effect observed NOAEC 1 131 mg/m³ (chronic, rat)
Inhalation route - local effects:
Adverse effect observed NOAEC 1 131 mg/m³ (chronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 37 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 29 6
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: in vivo
  • 21 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study 11 7
Supporting study 2
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 7 summaries submitted
  • 4 summaries processed
Toxicity - InVivo
Adverse effect observed (positive)

Carcinogenicity

Study results
  • 19 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 11 5
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 7 summaries submitted
  • 3 summaries processed
Oral route:
Adverse effect observed LOAEL 25 mg/kg bw/day (chronic, rat)
Inhalation route:
No adverse effect observed NOAEC 4 522 mg/m³ (chronic, rat)

Toxicity to reproduction

Study results
Study data: reproduction
  • 19 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 9 1
Supporting study 3
Weight of evidence
Other 4
Data waiving
Not feasible
Sci. unjustified 2
Exposure cons.
Other
Study data: developmental
  • 34 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 20 4
Supporting study
Weight of evidence 1
Other 8
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: other studies
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other 1
Data waiving
no waivers
M/C Summaries
  • 7 summaries submitted
  • 2 summaries processed
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 60 mg/kg bw/day (subacute, rat)

Neurotoxicity

Study results
  • 14 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 7 5
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 4 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Immunotoxicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant