Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 271-138-9 | CAS number: 68516-20-1 A complex combination of hydrocarbons produced by the distillation of products from a steam-cracking process. It consists predominantly of aromatic hydrocarbons having carbon numbers predominantly in the range of C7 through C12 and boiling in the range of approximately 130°C to 220°C(266°F to 428°F).
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Non-human information
A maximisation test in accordance with EU guideline B6 (Skin sensitisation) was performed by NOTOX (1996) to assess the sensitisation potential of toluene in guinea pigs. A grade 1 reaction (discrete or patchy erythema) was seen in 1/20 tested animals in response to challenge with a 50% solution. No other skin reactions were observed. It was concluded that toluene was not a skin sensitiser in this study.
Human information
There are no reports of skin sensitisation in humans attributed to toluene.
Migrated from Short description of key information:
The available animal data are sufficient to conclude that toluene is not a skin sensitiser. This is supported by the lack of human case reports for this high tonnage and widely used material.
Justification for selection of skin sensitisation endpoint:
Results from a guideline study provide no evidence of a potential to induce or elicit skin sensitisation
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No data animal or human data have been found with regard to respiratory sensitisation.
Migrated from Short description of key information:
No data have been found concerning respiratory sensitisation and there are no indications that toluene is a respiratory allergen.
Justification for selection of respiratory sensitisation endpoint:
No data have been found concerning respiratory sensitisation and there are no indications that toluene is a respiratory allergen
Justification for classification or non-classification
The animal data supported by the lack of human case studies reporting skin or respiratory sensitisation allow for the overall conclusion that, according to the GHS / CLP criteria, toluene does not require classification for sensitisation properties.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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