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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2011-08-03 to 2011-08-29
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was conducted according to a relevant guideline without deviations. It was not carried out according to GLP, but it was performed in a test facility which has been certified to be in compliance with the principles of GLP.
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
The shake flask method was used rather than the column elution to avoid any changes in crystal structure during deposition
GLP compliance:
no
Remarks:
GLP compliant facility
Type of method:
flask method
Water solubility:
8.7 mg/L
Temp.:
20 °C
pH:
>= 7.12 - <= 7.46

 Sample number  W1  W2  W5  W2  W4  W6
 Amount of test sample dispersed in 50ml water (mg)  10.0  10.1

 10.0

 10.2  10.0  10.0
 Number of days at 30.0°C  3  2  1  3  2  1
 Number of days at 25.0°C  1  1  1  1  1  1
 Centrifugation time (Minutes)  40  40  40  40  40  40
 Centrifugation Speed (G)  30000  30000  30000  48000  48000  48000
 pH of clear solution  7.19  7.46  7.21  7.42  7.34  7.12

 Water solubility (mg/l)

1st determination

2nd determination

Average

8.109

8.095

8.102

8.828

8.741

8.785

9.000

8.968

8.984

9.763

9.762

9.763

8.379

8.380

8.380

8.198

8.175

8.187

 Average solubility per centrifuge speed (mg/l)

  8.624     

  8.776     

 Relative SD (%)   4.81        8.76     
 Total average solubility (mg/l)

     8.7           

 Total relative SD (%)

     6.8           

Conclusions:
Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The solubility in water of CA4915 has been determined using the shake flask method to be, correct to two significant figures:

8.7 mg/l at 20 °C
Executive summary:

The shake flask method was used in order not to alter the crystal structure of the test material. A total of six measurements of water solubility were recorded and all were in good agreement with each other giving confidence in the conditions of the study and the result. The study is considered adequate and reliable. The water solubility was determined to be 8.7mg/l at 20°C.

Description of key information

8.7 mg/L at 20 °C, OECD 105, shake flask method, Vijayakamar 2011

Key value for chemical safety assessment

Water solubility:
8.7 mg/L
at the temperature of:
20 °C

Additional information

Only a single study conducted according to guidelines is available for this endpoint. The study is considered to be relevant, reliable (Klimisch 1) and adequate for the purposes of risk assessment, classification and labelling.