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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2011-07-21 to 2011-08-03 (experimental phase)
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was conducted according to a relevant guideline without deviations. It was not carried out according to GLP, but it was performed in a test facility which has been certified to be in compliance with the principles of GLP.
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
adopted March 23, 2006
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
amended 23 July 2009
Deviations:
no
GLP compliance:
no
Remarks:
However, the study was performed in a test facility which has been certified to be in compliance with the principles of GLP.
Type of method:
gas saturation method
Temp.:
48.8 °C
Vapour pressure:
0.001 Pa
Remarks on result:
other: experimentally determined value
Temp.:
59.6 °C
Vapour pressure:
0.005 Pa
Remarks on result:
other: experimentally determined value
Temp.:
79.3 °C
Vapour pressure:
0.005 Pa
Remarks on result:
other: experimentally determined value
Temp.:
20 °C
Vapour pressure:
0 Pa
Remarks on result:
other: extrapolated value
Temp.:
25 °C
Vapour pressure:
0 Pa
Remarks on result:
other: extrapolated value

Calibration of HPLC system

The r² fit was 0.9999 (optimum 1.0000). This reflects the suitability of the HPLC-system within the calibration range of 4.825 μg/mL to 96.5 μg/mL of the test item.

Trapping efficacy

The trapping efficiency of the test item in the first cooling trap was very good. 100% of the test item was trapped in the first cooling trap.

Results of the Vapour Pressure Determination

Column No.

Temp. [°C]

Volume* [mL]

Amount of

test item

in trap 1 [µg]

Amount of test

item in trap 2

[µg]

Total

amount of

test item [µg]

Vapour

Pressure [Pa]

Average

vapour

pressure [Pa]

1

48.78

 

278393

28.954

0

28.954

1.1 x 10-3

1.22 x 10-3

2

347650

43.389

0

43.389

1.3 x 10-3

3

417249

52.369

0

52.369

1.1 x 10-3

1

59.55

 

136740

58.960

0

58.960

4.6 x 10-3

4.88 x 10-3

2

169313

83.118

0

83.118

5.2 x 10-3

3

201721

90.858

0

90.858

4.8 x 10-3

1

79.30

 

288610

1331.528

0

1331.528

5.2 x 10-3

5.22 x 10-3

2

358414

1645.232

0

1645.232

5.2 x 10-3

3

441278

2044.129

0

2044.129

5.2 x 10-3

 

*Corrected volume at test temperature 

Vapour pressure curve for extrapolation

The logarithm of the measured vapour pressure was fitted against 1/T. The following equation was obtained:

ln(VP) = - 13971.86 · 1/T + 36.68, where

VP: Vapour pressure [Pa]

T: Temperature [K]

The coefficient of determination was r²=0.9985.

Conclusions:
The vapour pressure was determined to be 1.7E-05 Pa at 20 °C and 3.8E-05 Pa at 25 °C by extrapolation. The study is considered to be adequate and reliable.
Executive summary:

The vapour pressure of the test item was determined according to the OECD guideline No. 104, “Vapour Pressure” (2006).

The gas saturation method was chosen for the determination. The test was performed at 79.3, 59.6 and 48.8 °C. The amount of transferred test item in each of the condensation tubes was determined by HPLC analysis and the vapour pressure at the test temperatures was determined. The vapour pressure of the test item at 25 °C and at 20 °C was extrapolated from the obtained vapour pressure curve according to the simplified Clausius-Clapeyron equation and was calculated to be 1.7E-05 Pa at 20 °C and 3.8E-05 Pa at 25 °C.

Description of key information

1.7E-05 Pa at 20 °C and 3.8E-05 Pa at 25 °C by extrapolation, OECD 104, gas saturation method, Weissenfeld 2011.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
20 °C

Additional information

The vapour pressure of the test item was determined according to the OECD guideline No. 104, “Vapour Pressure” (2006).

The gas saturation method was chosen for the determination. The test was performed at 79.3, 59.6 and 48.8 °C. The amount of transferred test item in each of the condensation tubes was determined by HPLC analysis and the vapour pressure at the test temperatures was determined. The vapour pressure of the test item at 25 °C and at 20 °C was extrapolated from the obtained vapour pressure curve according to the simplified Clausius-Clapeyron equation and was calculated to be 1.7E-05 Pa at 20 °C and 3.8E-05 Pa at 25 °C.