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EC number: 232-055-3 | CAS number: 7784-25-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Two standardised test on Al2(SO4)3 and two non standardised tests on (NH4)2SO4 and AlNH4(SO4)2 were performed on two different freshwater fish species and one marine water fish species. The greatest sensitivity observed was related to aluminium toxicty at pH ranging between 4.8-5. The lowest reliable LC50(96h) correspond to 158 mg/L of AlNH4(SO4)2.12H2O.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 158 mg/L
Marine water fish
Marine water fish
- Effect concentration:
- 158 mg/L
Additional information
Two test performed according to OECD 203 guideline and GLP were performed with Al2(SO4)3on Danio rerio under static and semi static conditions. During the static test no pH adjustment was made and the pH decrease up 4.2. However, the study included further testing to demonstrate that toxicity was related to aluminium and not to low pH values.In this test an LC50 (96h) was found of 1 mg/L Dissolved Al or 158 mg/L AlNH4(SO4)2.12H2O at a pH of approximately 4.8-5.During the second test under semi-static, the pH was adjusted between 7.4 and 8.0. No effects were found in this test, therefore, an LC50 (96h) greater than 0.247 mg/L Dissolved Al or 1443 mg/LAlNH4(SO4)2.12H2O was determined.
An 96h acute toxicity test of (NH4)2SO4to juvenile Salmo gairdneri and not performed according to international guidelines was reported in a peer review publication. The methodology used is scientifically acceptable and even if important information was not reported on tested concentrations the results are considered reliable. Ten fish per tank were exposed in each concentration and one control fish was realized. Tests were performed with a mean pH of 7.9; and a mean temperature of 12.4°C. Total ammonia nitrogen was measured and un-ionized ammonia concentrations were calculated. The LC50 (96h) was 0.764 mg NH3/L corresponding to 924 mg/L AlNH4(SO4)2.12H2O.
Another peer review publication reported the toxicity of the salt AlNH4(SO4)2.12H2O to the marine water fish Fundulus heteroclitus after 48h of exposure at two different salinities. The test was not performed according to international guidelines and the report is missing important information so the study was assessed as not assignable. The pH was not adjusted and is expected to have ranged between 4 to 7.6 and to have been the immediate cause of death in some test. However the methodology is scientifically acceptable and the results are sufficiently reliable to be use in a weight of evidence approach. EC50 (48h) of 3.6 mg/L and 27.5 mg/L Total Al corresponding to 60.5 and 461.4 mg/L AlNH4(SO4)2.12H2O at a salinity of 6.6 and 17 ppt, respectively have been determined. The result on the toxicity of the salt confirms the result on the dissociation products reinforcing the read across approach reliability.
The results show that the greatest sensitivity was observed on the marine water fish Fundulus heteroclitus during the 48h exposure test with AlNH4(SO4)2.12H2O. During this test, the pH ranged between 4 and 7.6 and therefore the toxicity observed seems related to aluminium. However, this result cannot be validated because the low pH might have been the immediate cause of death. On the other hand, this assumption is confirmed by the static test with Al2(SO4)3on Danio rerio where a comparable level of toxicity was found (taking into account the interspecies differences) at a pH of 4.8-5. No toxicity of aluminium is observed when the pH is maintained between 7.4 and 8.0 as shown in the semi static test on Al2(SO4)3. At the same range of pH (7.9-8), ammoniac show toxicity on Salmo gairdneri juveniles exposed to (NH4)2SO4 during 96h. However the observed acute toxicity of aluminium on fish is around 2 and 15 times higher than the acute toxicity of ammoniac related to the salt concentration independently of the pH value.
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