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Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

Acute toxicity of tert-dodecanethiol to freshwater fish was assessed in 3 studies using a weight of evidence approach. No mortality or sublethal effect was observed for a 96 hours exposure at values already higher than the limit of solubility.

Key value for chemical safety assessment

Additional information

Two acute fish (Danio rerio and Oncorhynchus mykiss) toxicity tests were performed using OECD TG 203, both using a closed design, one in a limit test with a WAF prepared at 100mg/L and the second at a series of lower concentrations but all greater than the limit of solubility. Analytics were insufficient to consider either of these studies as valid. In the zebrafish study, no effect was observed for mortality or sublethal observations but as the tanks had been opened regularly the study is considered as technically flawed. For the trout study inconsistent effects were found in the mid-concentration range but not at lower or higher concentrations consistent with physical effects. In this study insufficient data were available to assess reliability but the test method does not appear otherwise to have been technically flawed.

A further study on O. latipes was conducted in open conditions and the fish were exposed to the substance in an emuslifier was therefore not used in a WoE approach.

Four other studies were also located on fish and are mentioned in the review paper by Thomas & Comber (2013) but are not included in the IUCLID as too little information beyond the effect concentration is available. In all cases no effects were found at or close to the solubility limit of the substance.

The conclusion is no effect on fish at the solubility limit using a weight of evidence approach.