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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1975
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study was conducted according to accepted scientific standards at time of performance. Sufficiently documented and reported.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Repeated dermal application of test material
GLP compliance:
no
Test type:
other: dermal application
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sulfonic acids, C14-17-sec-alkane, sodium salts
EC Number:
307-055-2
EC Name:
Sulfonic acids, C14-17-sec-alkane, sodium salts
Cas Number:
97489-15-1
Molecular formula:
H3C-(CH2)m-CH-(SO3Na)-(CH2)n-CH3
IUPAC Name:
Sulfonic acids, C14-17-sec-alkane, sodium salts
Constituent 2
Reference substance name:
Hostapur SAS 60
IUPAC Name:
Hostapur SAS 60
Details on test material:
- Name of test material (as cited in study report): Hostapur SAS 60

- Physical state: pasty
- Analytical purity: 60%
- Composition of test material, percentage of components: 60% Hostapur SAS 93, water
- Isomers composition: n.a.
- Purity test date: 1974-09-03
- Lot/batch No.: no data
- Expiration date of the lot/batch: 1976-10-01
- Radiochemical purity (if radiolabelling): n.a.
- Specific activity (if radiolabelling): n.a.
- Locations of the label (if radiolabelling): n.a.
- Expiration date of radiochemical substance (if radiolabelling): n.a.
- Stability under test conditions: stability and homogeneity guaranteed
- Storage condition of test material: in darkness at room temperature
- Other:

Test animals

Species:
mouse
Strain:
CD-1
Sex:
female
Details on test animals or test system and environmental conditions:
see section 7.5.2 Repeated dose toxicity: dermal

Administration / exposure

Type of coverage:
open
Vehicle:
water
Details on dermal exposure:
see section 7.5.2 Repeated dose toxicity: dermal
Duration of exposure:
see section 7.5.2 Repeated dose toxicity: dermal
Doses:
0.1 mL of up to 32% (w/v) per mouse per day
No. of animals per sex per dose:
25
Control animals:
yes
Details on study design:
see section 7.5.2 Repeated dose toxicity: dermal

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
approximate LD50
Effect level:
> 2 000 mg/kg bw
Remarks on result:
other: calculated
Mortality:
No mortality
Clinical signs:
other: see section 7.5.2 Repeated dose toxicity: dermal
Gross pathology:
see section 7.5.2 Repeated dose toxicity: dermal
Other findings:
see section 7.5.2 Repeated dose toxicity: dermal

Any other information on results incl. tables

see section 7.5.2 Repeated dose toxicity: dermal

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Repeated dermal application on mice of test material solutions as high as 32 % (w/v), 5 days per week for 4 weeks resulted neither in mortality nor
substance related systemic toxicity. The acute dermal toxicity of the test material is therefore calculated to be gretaer 2000 mg/kg body weight.
Executive summary:

see section 7.5.2 Repeated dose toxicity: dermal