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EC number: 307-055-2 | CAS number: 97489-15-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
After single oral application of 0.5, 5.3 or 51 mg sec-alkane sulfonate-sodium salt SAS - 14C via gavage to 3 groups of 6 male rats per group, blood levels reached a maximum about 2 to 6 hours after administration. Elimination from the blood was biphasic with biological half-lives of 11 and 65 hours. Up to 17 % of the administered radioactivity was exhaled as CO2; approximately 30 % was excreted via urine and about 45 % with faeces. In total more than 90 % of the applied radioactivity was excreted within the first 24 hours after application. Indications of bioaccumulation were not revealed as demonstrated by very low residual radioactivity (< 1 ppm) in organs after 7 days.
Dermal application of about 0.25 mg sec-alkane sulfonate-sodium salt SAS - 14C onto approximately 6 cm2 shaved back skin for 1.25 hours revealed maxima in blood levels about 2 to 6 hours p.a. Elimination half-life was in average about 41 hours (air approximately 15 %, urine approximately 18 %, faeces approximately 31 %). Most radioactivity was found in the bandage (approximately 35 %) whereas only about 2.2 % was detected in the treated skin 7 days p.a. The available data point to a low skin penetration potential of sec-alkane sulfonate-sodium salts SAS.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - dermal (%):
- 1
Additional information
Single oral or dermal administration of radiolabelled sec-alkane sulfonate-sodium salts SAS-C14 revealed that the kinetic behaviour is independent of the administered dose. After oral as well as after dermal exposure, highest blood levels occurred approximately 2 to 6 hours after application. Elimination was biphasic with half-lifes of about 11 and 65 hours after oral and approximately 41 hours after dermal exposure. In both cases more than 90% of the applied doses were eliminated within 24 hours. The available data point to a low skin penetration potential of sec-alkane sulfonates SAS. Indications of a bioaccumulative behaviour were not found. Residuals of less than 1 ppm of the administered dose were found in organs and tissues 7 days p.a.
Discussion on bioaccumulation potential result:
Experimental studies using radiolabelled sec-alkane sulfonate-sodium salts SAS have not revealed indications of a significant bioaccumulation potential.
Discussion on absorption rate:
Experimental studies using radiolabelled test material have not revealed indications that sec-alkane sulfonate-sodium salts SAS is significantly absorbed through skin after dermal treatment. This result is in line with data for ionic substances where percutaneous absorption is considered to be very low. A dermal penetration rate of approximately 1% for sec-alkane sulfonate-sodium salts SAS as for anionic substances in general is therefore considered scientifically justified.
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