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EC number: 202-625-6 | CAS number: 97-99-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014-06-18 to 2014-06-19
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- isoteniscope
- Key result
- Test no.:
- #1
- Temp.:
- 25 °C
- Vapour pressure:
- 142 Pa
- Remarks on result:
- other: The result was extrapolated from measurements made at elevated temperature and therefore the reviewer has attempted to assess the uncertainty associated with the extrapolation.
- Key result
- Test no.:
- #2
- Temp.:
- 20 °C
- Vapour pressure:
- ca. 100 Pa
- Key result
- Test no.:
- #3
- Temp.:
- 30 °C
- Vapour pressure:
- ca. 180 Pa
- Key result
- Test no.:
- #4
- Temp.:
- 40 °C
- Vapour pressure:
- ca. 340 Pa
- Key result
- Test no.:
- #5
- Temp.:
- 50 °C
- Vapour pressure:
- ca. 600 Pa
- Transition / decomposition:
- no
- Conclusions:
- A vapour pressure of 142±13 Pa at 25°C was determined for the substance in accordance with OECD 104 and in compliance with GLP. The result is considered reliable.
Reference
Recorded temperatures, manometer readings and resulting calculated values of vapour pressure are shown in the tables below
Run 1
Table 1: vapour pressure data
LHS column (cmHg) |
RHS column (cmHg) |
Temperature (°C) |
Vapour pressure (Pa) |
Temperature (K) |
Reciprocal temperature (1/K) |
log10VP |
56.1 |
14.9 |
157.0 |
54928.82 |
430.15 |
0.002324770 |
4.739800236 |
55.6 |
15.4 |
156.0 |
53595.59 |
429.15 |
0.002330188 |
4.729129073 |
54.5 |
16.5 |
154.1 |
50662.50 |
427.25 |
0.002340550 |
4.704686617 |
53.9 |
17.1 |
152.8 |
49062.63 |
425.95 |
0.002347693 |
4.690750839 |
53.2 |
17.8 |
151.6 |
47196.12 |
424.75 |
0.002354326 |
4.673906282 |
52.5 |
18.5 |
150.4 |
45329.61 |
423.55 |
0.002360996 |
4.656381937 |
51.4 |
19.6 |
148.3 |
42396.51 |
421.45 |
0.002372761 |
4.627330140 |
50.7 |
20.3 |
147.0 |
40530.00 |
420.15 |
0.002380102 |
4.607776604 |
50.0 |
21.0 |
145.6 |
38663.49 |
418.75 |
0.002388060 |
4.587301018 |
49.3 |
21.7 |
144.2 |
36796.97 |
417.35 |
0.002396070 |
4.565812102 |
48.7 |
22.3 |
142.9 |
35197.11 |
416.05 |
0.002403557 |
4.546506947 |
47.6 |
23.4 |
140.4 |
32264.01 |
413.55 |
0.002418087 |
4.508718386 |
47.1 |
23.9 |
139.2 |
30930.79 |
412.35 |
0.002425124 |
4.490391005 |
46.9 |
24.1 |
138.1 |
30397.50 |
411.25 |
0.002431611 |
4.482837867 |
46.0 |
25.0 |
136.4 |
27997.70 |
409.55 |
0.002441704 |
4.447122315 |
45.7 |
25.3 |
135.4 |
27197.76 |
408.55 |
0.002447681 |
4.434533188 |
45.3 |
25.7 |
134.0 |
26131.18 |
407.15 |
0.002456097 |
4.417159091 |
44.8 |
26.2 |
132.8 |
24797.96 |
405.95 |
0.002463358 |
4.394415964 |
44.4 |
26.6 |
131.6 |
23731.38 |
404.75 |
0.002470661 |
4.375323022 |
43.9 |
27.1 |
130.0 |
22398.16 |
403.15 |
0.002480466 |
4.350212302 |
43.5 |
27.5 |
128.6 |
21331.58 |
401.75 |
0.002489110 |
4.329023003 |
43.2 |
27.8 |
127.5 |
20531.64 |
400.65 |
0.002495944 |
4.312423741 |
A plot of log10[vapour pressure (Pa)] versus reciprocal temperature [1/T(K)] for Run 1 gives the following statistical data using an unweighted least square treatment
Slope = -2.53x103
Standard error in slope = 11.7
Intercept = 10.6
Standard error in intercept = 2.81x10-2
The results indicated the following vapour pressure relationship:
log10[vapour pressure (Pa)] = -2.53x103/temp (K) + 10.6
This yields a vapour pressure (Pa) at 298.15 K with a common logarithm of 2.14
Run 2
Table 2: vapour pressure data
LHS column (cmHg) |
RHS column (cmHg) |
Temperature (°C) |
Vapour pressure (Pa) |
Temperature (K) |
Reciprocal temperature (1/K) |
log10VP |
54.9 |
16.1 |
154.7 |
51729.08 |
427.85 |
0.002337268 |
4.713734746 |
54.5 |
16.5 |
153.8 |
50662.50 |
426.95 |
0.002342195 |
4.704686617 |
54.0 |
17.0 |
152.9 |
49329.28 |
426.05 |
0.002347142 |
4.693104744 |
53.2 |
17.8 |
151.5 |
47196.12 |
424.65 |
0.002354880 |
4.673906282 |
52.6 |
18.4 |
150.4 |
45596.25 |
423.55 |
0.002360996 |
4.658929126 |
52.0 |
19.0 |
149.2 |
43996.38 |
422.35 |
0.002367705 |
4.643416960 |
51.4 |
19.6 |
148.2 |
42396.51 |
421.35 |
0.002373324 |
4.627330140 |
50.8 |
20.2 |
146.9 |
40796.64 |
420.05 |
0.002380669 |
4.610624447 |
50.1 |
20.9 |
145.5 |
38930.13 |
418.65 |
0.002388630 |
4.590285872 |
49.5 |
21.5 |
144.3 |
37330.26 |
417.45 |
0.002395496 |
4.572061051 |
48.9 |
22.1 |
142.8 |
35730.39 |
415.95 |
0.002404135 |
4.553037814 |
48.3 |
22.7 |
141.5 |
34130.53 |
414.65 |
0.002411672 |
4.533142985 |
47.5 |
23.5 |
139.6 |
31997.37 |
412.75 |
0.002422774 |
4.505114262 |
47.0 |
24.0 |
138.6 |
30664.14 |
411.75 |
0.002428658 |
4.486630856 |
46.8 |
24.2 |
137.7 |
30130.86 |
410.85 |
0.002433978 |
4.479011459 |
46.2 |
24.8 |
136.6 |
28530.99 |
409.75 |
0.002440513 |
4.455316793 |
45.3 |
25.7 |
134.1 |
26131.18 |
407.25 |
0.002455494 |
4.417159091 |
45.0 |
26.0 |
132.9 |
25331.25 |
406.05 |
0.002462751 |
4.403656621 |
44.5 |
26.5 |
131.6 |
23998.03 |
404.75 |
0.002470661 |
4.380175525 |
44.0 |
27.0 |
130.0 |
22664.80 |
403.15 |
0.002480466 |
4.355351942 |
43.6 |
27.4 |
128.8 |
21598.22 |
401.95 |
0.002487872 |
4.334418035 |
43.3 |
27.7 |
127.6 |
20798.29 |
400.75 |
0.002495321 |
4.318027618 |
43.0 |
28.0 |
126.3 |
19998.36 |
399.45 |
0.002503442 |
4.300994279 |
A plot of log10[vapour pressure (Pa)] versus reciprocal temperature [1/T(K)] for Run 2 gives the following statistical data using an unweighted least square treatment
Slope = -2.53x103
Standard error in slope = 9.85
Intercept = 10.6
Standard error in intercept = 2.38x10-2
The results indicated the following vapour pressure relationship:
log10[vapour pressure (Pa)] = -2.53x103/temp (K) + 10.6
This yields a vapour pressure (Pa) at 298.15 K with a common logarithm of 2.15
Run 3
Table 3: vapour pressure data
LHS column (cmHg) |
RHS column (cmHg) |
Temperature (°C) |
Vapour pressure (Pa) |
Temperature (K) |
Reciprocal temperature (1/K) |
log10VP |
56.9 |
14.1 |
159.2 |
57061.97 |
432.35 |
0.002312941 |
4.756346789 |
55.8 |
15.2 |
157.7 |
54128.88 |
430.85 |
0.002320993 |
4.733429054 |
55.1 |
15.9 |
156.5 |
52262.37 |
429.65 |
0.002327476 |
4.718189087 |
54.1 |
16.9 |
154.6 |
49595.92 |
427.75 |
0.002337814 |
4.695445960 |
53.3 |
17.7 |
153.5 |
47462.76 |
426.65 |
0.002343842 |
4.676353018 |
52.5 |
18.5 |
152.0 |
45329.61 |
425.15 |
0.002352111 |
4.656381937 |
51.0 |
20.0 |
149.0 |
41329.93 |
422.15 |
0.002368826 |
4.616264714 |
50.0 |
21.0 |
147.1 |
38663.49 |
420.25 |
0.002379536 |
4.587301018 |
49.0 |
22.0 |
144.6 |
35997.04 |
417.75 |
0.002393776 |
4.556266784 |
48.7 |
22.3 |
144.1 |
35197.11 |
417.25 |
0.002396645 |
4.546506947 |
47.7 |
23.3 |
142.0 |
32530.66 |
415.15 |
0.002408768 |
4.512292846 |
47.0 |
24.0 |
139.6 |
30664.14 |
412.75 |
0.002422774 |
4.486630856 |
46.0 |
25.0 |
137.4 |
27997.70 |
410.55 |
0.002435757 |
4.447122315 |
45.5 |
25.5 |
136.0 |
26664.47 |
409.15 |
0.002444091 |
4.425933016 |
44.9 |
26.1 |
134.0 |
25064.61 |
407.15 |
0.002456097 |
4.399060869 |
44.0 |
27.0 |
130.8 |
22664.80 |
403.95 |
0.002475554 |
4.355351942 |
43.2 |
27.8 |
128.0 |
20531.64 |
401.15 |
0.002492833 |
4.312423741 |
42.4 |
28.6 |
125.7 |
18398.49 |
398.85 |
0.002507208 |
4.264782107 |
A plot of log10[vapour pressure (Pa)] versus reciprocal temperature [1/T(K)] for Run 3 gives the following statistical data using an unweighted least square treatment
Slope = -2.49x103
Standard error in slope = 13.3
Intercept = 10.5
Standard error in intercept = 3.18x10-2
The results indicated the following vapour pressure relationship:
log10[vapour pressure (Pa)] = -2.49x103/temp (K) + 10.5
This yields a vapour pressure (Pa) at 298.15 K with a common logarithm of 2.17
Summary of results
The extrapolated vapour pressure for each measurement is summarised in Table 4
Table 4: summary of vapour pressure data
run |
log10[vapour pressure (Pa)] at 25°C |
1 |
2.14 |
2 |
2.15 |
3 |
2.17 |
Mean |
2.15 |
vapour pressure |
142 |
The test item did not change in appearance under the conditions of the study
Reviewer's comment: The result (142 Pa) was extrapolated from measurements made at elevated temperature and therefore the reviewer has attempted to assess the uncertainty associated with the extrapolation. Based on the raw data, the reviewer has estimated the vapour pressure of the substance to be 142±13 Pa at 25°C.
Using the regression in the study report, the following vapour pressures at different temperatures were obtained by the reviewer.
|
Run 1 (log VP) |
Run 2 (log VP) |
Run 3 (log VP) |
Average |
Vapour pressure (Pa) |
20 |
1.969606 |
1.969606 |
2.006055 |
1.981756 |
95.8861 |
30 |
2.254297 |
2.254297 |
2.286244 |
2.264946 |
184.0542 |
40 |
2.520805 |
2.520805 |
2.548539 |
2.530049 |
338.8828 |
50 |
2.770819 |
2.770819 |
2.7946 |
2.778746 |
600.8218 |
Description of key information
Vapour pressure [tetrahydrofurfuryl alcohol]: 142±13 Pa at 25°C (OECD 104)
Key value for chemical safety assessment
- Vapour pressure:
- 142 Pa
- at the temperature of:
- 25 °C
Additional information
The vapour pressure of the submission substance has been recently determined. A vapour pressure of 142±13 Pa at 25°C was obtained for the substance using the isoteniscope method in accordance with OECD 104 and in compliance with GLP. The result was extrapolated from measurements at elevated temperature, the reviewer has therefore attempted to assess the uncertainty associated with the extrapolation. In addition, using the regression equations in the study report, vapour pressure values of approximately 100 Pa at 20°C, 180 Pa at 30°C, 340 Pa at 40°C and 600 Pa at 50°C were obtained by the study reviewer. The result is considered to be reliable and selected as key study. The key study is supported by a measured vapour pressure of 186 Pa at 25°C which was obtained for the substance in accordance with OECD 104 and in compliance with GLP. Also, a vapour pressure of 107 Pa at 25°C was reported from a reliable peer-reviewed source (Daubert and Danner 1989). The key study was selected as the most recent of the available reliable studies.
In secondary sources to which reliability could not be assigned, vapour pressures of 31 Pa at 20°C and 670 Pa at 50°C were reported for the substance. Similarly, in another secondary source (Pennakem 1973), raw vapour pressure results between temperature of 41 - 178°C were reported for the substance. Vapour pressure value of 2.3 mmHg (307 Pa) at 41.6°C was obtained for tetrahydrofurfuryl alcohol. Vapour pressure values of 82 Pa and 116 Pa at 20°C and 25°C were extrapolated by the reviewer from the raw data.
Variations in the vapour pressure of the substance may occur depending on the purity of the test substance and the test method used, however in the absence of a more reliable data, the vapour pressure result reported in the key study is used as a worst case value for assessment purposes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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