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Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2004-08-10 - 2004-09-2004
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Deviations:
no
GLP compliance:
yes
Radiolabelling:
no
Analytical monitoring:
not specified
Buffers:
- pH: 4.0
- Type and final molarity of buffer: 0.1 mol/L
- Composition of buffer: Sodium hydroxide solution (0.1 mol/L) of 2.0 mL and potassium hydrogen phthalate solution (0.1 mol/L) of 250 mL were adjusted to the constant volume of 500 mL with purified water


- pH: 7.0
- Type and final molarity of buffer: 0.1 mol/L
- Composition of buffer: Sodium hydroxide solution (0.1 mol/L) of 148.15 mL and potassium dihydrogen phosphate solution (0.1 mol/L) of 250 mL were adjusted to the constant volume of 500 mL with purified water.


- pH: 9.0
- Type and final molarity of buffer: 0.1 mol/L
- Composition of buffer: Sodium hydroxide solution (0.1 mol/L) of 106.5 mL and potassium chloride (0.1 mol/L) / boric acid (0.1 mol/L) of 250 mL were adjusted to the constant volume of 500 mL with purified water
Duration:
5 d
pH:
4
Temp.:
50
Initial conc. measured:
20 mg/L
Duration:
5 d
pH:
7
Temp.:
50
Initial conc. measured:
20 mg/L
Duration:
5 d
pH:
9
Temp.:
50
Initial conc. measured:
20 mg/L
Number of replicates:
Two replicates
Positive controls:
not specified
Negative controls:
not specified
Preliminary study:
Only the preliminary study was performed because the test substance was stable to hydrolys (half-life >1y)
Transformation products:
no
% Recovery:
101
pH:
4
Temp.:
50 °C
Duration:
5 d
% Recovery:
98.7
pH:
7
Temp.:
50 °C
Duration:
5 d
% Recovery:
99.5
pH:
9
Temp.:
50 °C
Duration:
5 d
Key result
pH:
4
Temp.:
50 °C
DT50:
> 1 yr
Remarks on result:
other: Result of preliminary study
Key result
pH:
7
Temp.:
50 °C
DT50:
> 1 yr
Remarks on result:
other: Result of preliminary study
Key result
pH:
9
Temp.:
50 °C
DT50:
> 1 yr
Remarks on result:
other: Result of preliminary study

Test result is as follows:

Test solution

Initial

Concentration

(mg/L)

Concentration

after 5 days

(mg/L)

Residual rate (%)

Measured

value

Mean

pH 4.0

19.8

20.0

101

101

19.9

101

pH 7.0

19.9

19.8

99.6

98.7

19.5

97.8

pH 9.0

19.7

19.7

100

99.5

19.3

99.0

Conclusions:
The residual rate of the test substance was more than 90% after 5 days in the test solution of pH 4.0, pH 7.0 and pH 9.0 at 50 ± 0.1°C. Therefore, it is considered that the half-life time of the test substance is over 1 year.

Description of key information

Hydrolysis (tetrahydrofurfuryl alcohol): >1 year at pH 4, 7 and 9 and 50°C (OECD 111, preliminary study).

Key value for chemical safety assessment

Additional information

A hydrolysis half-life of >1 year at pH 4, 7, 9 and 50°C was determined for the substance in a preliminary study in accordance with OECD 111 and in compliance with GLP. The result is considered to be reliable.

Since rate of hydrolysis is dependent on temperature (among other parameters), at ambient conditions (20 -25°C) the hydrolysis half-life is expected to be longer than 1 year.