Brief Profile

Diss Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
202-625-6
CAS no.:
97-99-4
Index number:
603-061-00-7
Molecular formula:
C5H10O2
SMILES:
OCC1CCCO1
InChI:
InChI=1/C5H10O2/c6-4-5-2-1-3-7-5/h5-6H,1-4H2
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
10
Of which contain:
0 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Danger! According to the harmonised classification and labelling (ATP06) approved by the European Union, this substance may damage the unborn child and is suspected of damaging fertility and causes serious eye irritation.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance may damage fertility or the unborn child.

Additionally, the classification provided by companies to ECHA in CLP notifications identifies that this substance is suspected of damaging fertility or the unborn child.

Breakdown of all 2316 C&L notifications submitted to ECHA

Eye Irrit. 2 H319 Harmonised Classification
Repr. 1B H360Df Harmonised Classification
Repr. 2 H361
Acute Tox. 4 H302
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/o/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • R
Officially recognised in the EU as Toxic to Reproduction (Harmonised C&L).
  • R
There is broad agreement in that a majority of data submitters agree this substance is Toxic to Reproduction (100% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 6 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 tonnes per annum.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing and at industrial sites.

This substance is used in the following products: plant protection products.

Other release to the environment of this substance is likely to occur from: outdoor use as processing aid.

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

This substance is used in the following products: plant protection products, adhesives and sealants and fertilisers.

This substance is used in the following areas: agriculture, forestry and fishing. This substance is used for the manufacture of: wood and wood products, pulp, paper and paper products, rubber products, plastic products and furniture.

This substance is used in the following activities or processes at workplace: transfer of chemicals, non-industrial spraying, treatment of articles by dipping and pouring, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure and batch processing in synthesis or formulation with opportunity for exposure.

Other release to the environment of this substance is likely to occur from: outdoor use and indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

This substance is used in the following products: adhesives and sealants, fertilisers, plant protection products and washing & cleaning products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers, batch processing in synthesis or formulation with opportunity for exposure, mixing in open batch processes and production of mixtures or articles by tabletting, compression, extrusion or pelletisation.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

This substance is used in the following products: adhesives and sealants, laboratory chemicals and washing & cleaning products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: scientific research and development. This substance is used for the manufacture of: chemicals, wood and wood products, rubber products, plastic products, furniture and pulp, paper and paper products.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

Precautions for using this substance have been recommended by its registrants under REACH, as follows:

General statements

Keep out of reach of children.

Prevention statements

When handling this substance: obtain special instructions before use; wash parts of the body (as specified by manufacturer/supplier)in contact with substance thoroughly after handling; wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier.

Storage statements

Store this substance locked up.

Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Aceto France SAS, 3 Place Giovanni da Verrazzano 69009 Lyon France
  • Chemical Inspections & Regulation Services Limited on behalf of Zhucheng Taisheng Chemical Co., Ltd, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Demasa Trading B.V., Rotterdam Airportplein 33 3045 AP Rotterdam Netherlands
  • International Furan Chemicals, Rotterdam Airportplein 33 3045 AP Rotterdam Netherlands
  • minasolve S.A.S., 145 chemin des lilas 59310 Beuvry la foret France
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • HH Compliance Ltd., Rubicon Building, CIT-Campus Bishopstown none Cork Ireland
  • Monument Chemical_ORBP, Haven 1972, Ketenislaan 3 9130 Kallo (Kieldrecht) Belgium
  • Syngenta Ltd, Jealott’s Hill International Research Centre RG42 6EY Bracknell Berkshire United Kingdom
  • Thomas Swan & Co. Ltd., Rotary Way DH8 7ND Consett Co. Durham United Kingdom

Substance names and other identifiers

2-(Hydroxymethyl)tetrahydrofuran
Other
2-Furanmethanol, tetrahydro-
Other
Furfuryl alcohol, tetrahydro-
Other
Furfuryl alcohol, tetrahydro- (8CI)
Other
QO Thfa
Other
Tetrahydro-2-furancarbinol
Other
Tetrahydro-2-furanmethanol
Other
Tetrahydro-2-furanylmethanol
Other
Tetrahydro-2-furfuryl alcohol
Other
tetrahydro-2-furyl-methanol; tetrahydrofurfuryl alcohol
FCM Active and Intelligent Materials - CMRs not allowed for use, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
Tetrahydro-2-furylmethanol
C&L Inventory, Other, Cosmetic Products Regulation, Annex II - Prohibited Substances
Tetrahydrofurfuryl alcohol
EC Inventory, C&L Inventory, REACH pre-registration
Tetrahydrofurfuryl alcohol
C&L Inventory, REACH pre-registration, Other
Tetrahydrofurfurylalkohol
Other
Tetrahydrofuryl carbinol
Other
Tetrahydrofurylalkohol
Other
THFA
Other
2-(hidroksimetil)tetrahidrofuran (sl)
C&L Inventory
2-(hydroksymetylo)oksolan (pl)
C&L Inventory
2-(hydroxymethyl)tetrahydrofuran (cs)
C&L Inventory
2-hidroximetiltetrahidrofurano (es)
C&L Inventory
2-hydroxymethyloxolan (da)
C&L Inventory
2-Hydroxymethyltetrahydrofuran (de)
C&L Inventory
alcohol tetrahidrofurfurílico (es)
C&L Inventory
alcool tetraidrofurfurilico (it)
C&L Inventory
alcool tétrahydrofurfurylique (fr)
C&L Inventory
alkohol tetrahydrofurfurylowy (pl)
C&L Inventory
tetrahidro-2-furil-metanol (hr)
C&L Inventory
tetrahidro-2-furilmetanol (hu)
C&L Inventory
tetrahidro-2-furilmetanol (ro)
C&L Inventory
tetrahidro-2-furilmetanolis (lt)
C&L Inventory
tetrahidro-2-furilmetanols (lv)
C&L Inventory
tetrahidrofurfuril alcool (ro)
C&L Inventory
tetrahidrofurfuril alkohol (sl)
C&L Inventory
tetrahidrofurfuril-alkohol (hr)
C&L Inventory
tetrahidrofurfuril-alkohol (hu)
C&L Inventory
tetrahidrofurfurilo alkoholis (lt)
C&L Inventory
tetrahidrofurfurilspirts (lv)
C&L Inventory
tetrahydro-2-furfurylmethanol (nl)
C&L Inventory
tetrahydro-2-furylmetanol (no)
C&L Inventory
tetrahydro-2-furylometanol (pl)
C&L Inventory
Tetrahydro-2-furyylimetanoli (fi)
C&L Inventory
tetrahydrofurfurylalkohol (cs)
C&L Inventory
tetrahydrofurfurylalkohol (da)
C&L Inventory
Tetrahydrofurfurylalkohol (de)
C&L Inventory
tetrahydrofurfurylalkohol (no)
C&L Inventory
tetrahydrofurfurylalkohol (sk)
C&L Inventory
tetrahydrofurfurylalkohol (sv)
C&L Inventory
tetrahydrofurán-2-metanol (sk)
C&L Inventory
Tetrahüdro-2-furüülmetanool (et)
C&L Inventory
Tetrahüdrofurüülalkohol (et)
C&L Inventory
tetraidro-2-furfurilmetanol (pt)
C&L Inventory
tetraidro-2-furilmetanolo (it)
C&L Inventory
tétrahydro-2-furyl-méthanol; alcool tétrahydrofurfurylique (fr)
C&L Inventory
álcool tetraidrofurfurílico (pt)
C&L Inventory
τετραϋδροφουρφουρυλαλκοόλη 2-υδροξυμεθυλοτετραϋδροφουράνιο (el)
C&L Inventory
тeтрахидрофурфурилов алкохол (bg)
C&L Inventory
тетрахидро-2-фурил метанол (bg)
C&L Inventory
2-Furanmethanol, tetrahydro-
Other
(oxolan-2-yl)methanol
Other
(tetrahydro-furan-2-yl)-methanol
C&L Inventory
(tetrahydro-furan-2-yl)-methanol 2-Furanmethanol, tetrahydro-
C&L Inventory
(tetrahydrofuran-2-yl)methanol
C&L Inventory
2-TETRAHYDROFURYLMETHANOL
C&L Inventory
Furfuryl alcohol, tetrahydro- (8CI); (Tetrahydrofuran-2-yl)methanol; (±)-Tetrahydrofurfuryl alcohol; 2-(Hydroxymethyl)tetrahydrofuran; NSC 15434; QO THFA; Rac-(Tetrahydrofuran-2-yl)methanol; THFA; Tetrahydro-2-furancarbinol; Tetrahydro-2-furanmethanol; Tetrahydro-2-furanylmethanol; Tetrahydro-2-furylmethanol;
Registration dossier
oxolan-2-yl methanol
C&L Inventory
oxolan-2-ylmethanol
C&L Inventory, Registration dossier, Other
Tetrahydro-2-furanmethanol
C&L Inventory
Tetrahydro-2-furanylmethanol
Registration dossier
tetrahydro-2-furylmethanol
C&L Inventory
tetrahydro-2furylmethanol
C&L Inventory
Tetrahydrofuran-2-ylmethanol
C&L Inventory, Registration dossier
Tetrahydrofurfuryl
C&L Inventory
TETRAHYDROFURFURYL ALCOHOL
C&L Inventory, Registration dossier
tetrahydrofurfuryl alcohol
C&L Inventory, Registration dossier
Tetrahydrofurfurylalkohol
C&L Inventory
THFA, Tetrahydro-2-furancarbinol, Tetrahydro-2-furanylmethanol, Tetrahydro-2-furylmethanol, Tetrahydrofurfuryl alcohol
Registration dossier
THFA
Registration dossier
603-061-00-7
Index number
C&L Inventory
72074-94-3
CAS number
Other
72074-94-3
Deleted CAS number
Other
82853-20-1
CAS number
Other
82853-20-1
Deleted CAS number
Other
97-99-4
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, FCM Active and Intelligent Materials - CMRs not allowed for use, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, End-of-Life Vehicles Directive - Hazardous Substances, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 5 studies submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Liquid (100%) [1]
C Form
Liquid (100%) [1]
C Substance type
Organic (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Liquid (100%)

Melting/freezing point

Study results
  • 6 studies submitted
  • 1 study processed
R Melting / freezing point
-120 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Melting / freezing point at 101 325 Pa
-120 °C

Boiling point

Study results
  • 6 studies submitted
  • 1 study processed
R Boiling point
177.7 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 5
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Boiling point at 101 325 Pa
177.7 °C

Density

Study results
  • 5 studies submitted
  • 2 studies processed
R Density
1.052 g/cm³ @ 20 °C [1]
R Relative density
1.045 - 1.054 @ 20 - 31 °C [3]

Type of Study provided
Studies with data
Key study
Supporting study 3
Weight of evidence 2
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Relative density at 20°C
1.05

Vapour pressure

Study results
  • 5 studies submitted
  • 1 study processed
R Vapour pressure
1 - 6 hPa @ 20 - 50 °C [5]

Type of Study provided
Studies with data
Key study 1
Supporting study 3 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Vapour pressure
1.42 hPa @ 25 °C

Partition coefficient

Study results
  • 2 studies submitted
  • 1 study processed
R Pow
0.722 @ 24.7 °C and pH 6.7 - 6.8 [1]
R Log Pow
-0.14 @ 24.7 °C and pH 6.7 - 6.8 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Log Kow (Log Pow)
-0.14 @ 24.7 °C

Water solubility

Study results
  • 3 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
250 g/L @ 20 °C and pH 4.6 - 4.7 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Water solubility
250 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Flash point

Study results
  • 4 studies submitted
  • 1 study processed
R Flash point
73 °C @ 101.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Flash point at 101 325 Pa
73 °C

Auto flammability

Study results
  • 4 studies submitted
  • 1 study processed
R Autoflammability / self-ignition
282 °C @ 102.3 kPa [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Autoflammability / self-ignition at 101 325 Pa
282 °C

Flammability

Study results
  • 7 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 4
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified 2
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Flammability
Not classified (100%)

Explosiveness

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Explosiveness
Non-explosive (100%)

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
C Summaries
  • 1 summary submitted
  • 1 summary processed
Oxidising
Non oxidising (100%)

Oxidation reduction potential

Data not provided by the registrant

pH

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers

No summary exists for this scientific endpoint

Dissociation constant

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 1 study submitted
  • 1 study processed
R dynamic viscosity (in mPa s)
6.24 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Dynamic viscosity at 20 °C
6.24 mPa.s

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 1 summary submitted
  • 1 summary processed
Half life in air
16.8 h
Degradation rate constant with OH radicals
0 cm³ molecule-1 d-1

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in soil

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in water - screening tests

Study results
  • 2 studies submitted
  • 1 study processed
C Interpretation of results
Readily biodegradable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Study results
  • 0 studies submitted
  • 0 studies processed

No data available

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 1 summary submitted
  • 1 summary processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 1.9 mg/L (1)
Intermittent releases (freshwater) 917 µg/L (1)
Marine water 190 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) 10 mg/L (1)
Sediment (freshwater) 8.6 mg/kg sediment dw (1)
Sediment (marine water) 860 µg/kg sediment dw (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil 600 µg/kg soil dw (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
LC50 (4 days) 101 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to fish

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (48 h) 91.7 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
NOEC (21 days) 95.1 mg/L [1]
LOEC (21 days) 95.1 mg/L [1]
EC50 (21 days) 95.1 mg/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 1 study submitted
  • 1 study processed
P/RResults
EC50 (72 h) 98.9 mg/L [2]
NOEC (72 h) 98.9 mg/L [2]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Data not provided by the registrant

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to terrestrial plants

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 1 summary submitted
  • 1 summary processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1.4 mg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 1 mg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
Low hazard (no threshold derived)
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 250 µg/m³ repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 500 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 175 µg/kg bw/day repeated dose toxicity
Acute /short term: No hazard identified
EYE Exposure
Low hazard (no threshold derived)

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Acute toxicity

Study results
oral
  • 1 study submitted
  • 1 study processed
P/RResults
LD50 2 000 mg/kg bw (rat) [1]
M/CInterpretations of results
GHS criteria not met [1]

Type of Study provided
oral
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
inhalation
  • 1 study submitted
  • 1 study processed
M/CInterpretations of results
GHS criteria not met [1]

inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
other routes
  • 0 studies submitted
  • 0 studies processed

No data available

other routes
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route:
Adverse effect observed LD50 2 000 mg/kg bw
Inhalation route:
No adverse effect observed LC50 3 100 mg/m³

Irritation / corrosion

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: eye
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin
No adverse effect observed (not irritating)
Eye
Adverse effect observed (irritating)
Respiratory
No study available

Sensitisation

Study results
Study data: skin
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No study available

Repeated dose toxicity

Study results
Study data: oral
  • 2 studies submitted
  • 1 study processed
P/RResults
NOAEL (rat): 500 - 1 000 ppm [2]

Type of Study provided
Study data: oral
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: inhalation
  • 1 study submitted
  • 1 study processed
P/RResults
NOAEC (rat): 50 ppm [1]
LOAEC (rat): 50 ppm [1]

Study data: inhalation
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal
  • 1 study submitted
  • 1 study processed
P/RResults
NOAEL (rat): 100 - 300 mg/kg bw/day [2]

Study data: dermal
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Oral route - systemic effects:
Adverse effect observed NOAEL 35 mg/kg bw/day (subchronic, rat)
Dermal route - systemic effects:
Adverse effect observed NOAEL 100 mg/kg bw/day (subchronic, rat)
Inhalation route - systemic effects:
Adverse effect observed LOAEC 209 mg/m³ (subchronic, rat)

Genetic toxicity

Study results
Study data: in vitro
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study 3
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Study data: in vivo
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Toxicity - InVitro
No adverse effect observed (negative)
Toxicity - InVivo
No study available

Carcinogenicity

Data not provided by the registrant

Toxicity to reproduction

Study results
Study data: reproduction
  • 9 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study 1
Supporting study 7
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: developmental
  • 4 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 1 summary submitted
  • 1 summary processed
Effect on fertility
Oral route:
Adverse effect observed NOAEL 50 mg/kg bw/day (subacute, rat)
Dermal route:
Adverse effect observed NOAEL 100 mg/kg bw/day (subchronic, rat)
Inhalation route:
Adverse effect observed NOAEC 200 mg/m³ (subchronic, rat)
Effect on developmental toxicity
Oral route:
Adverse effect observed NOAEL 50 mg/kg bw/day (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant