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EC number: 202-625-6 | CAS number: 97-99-4
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2004-11-25 to 2005-06-26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- gas chromatography
- Key result
- Type:
- Pow
- Partition coefficient:
- 0.722
- Temp.:
- 24.7 °C
- pH:
- ca. 6.7 - ca. 6.8
- Key result
- Type:
- log Pow
- Partition coefficient:
- -0.14
- Temp.:
- 24.7 °C
- pH:
- ca. 6.7 - ca. 6.8
- Details on results:
- See Table 2
- Conclusions:
- A log Kow of -0.14 at 24.7°C and pH 6.7 - 6.8 was determined for the substance in accordance with OECD 107 and in compliance with GLP. The result is considered reliable.
Reference
Table 2 : Measurement results of partition coefficient (Pow)
| Pow=Co/Cw | log Pow | |||||||||
| MeasuredValue | Mean | TotalMean | Standarddeviation | Measuredvalue | Mean | Totalmean | Standarddeviation | Maximumdifferance | ||
| Measurement condition-1 | a | 0.653 | 0.663 | 0.722 | 0.0471 | -0.19 | -0.18 | -0.14 | 0.0289 | 0.07 |
| b | 0.674 | -0.17 | ||||||||
| Measurement condition-2 | a | 0.737 | 0.743 | -0.13 | -0.13 | |||||
| b | 0.749 | -0.13 | ||||||||
| Measurement condition-3 | a | 0.762 | 0.761 | -0.12 | -0.12 | |||||
| b | 0.759 | -0.12 | ||||||||
Description of key information
Partition coefficient [tetrahydrofurfuryl alcohol]: -0.14 at 24.7°C and pH 6.7 - 6.8 (OECD 107)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.14
- at the temperature of:
- 24.7 °C
Additional information
A measured log Kow of -0.14 at 24.7°C and pH 6.7 - 6.8 was determined for the substance in accordance with OECD 107 and in compliance with GLP. The result is considered to be reliable and selected as key study. In a secondary source to which reliability could not be assigned, a limit log Kow of <3 was reported for the substance.
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