Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

1,2 Benzenedicarboxylic acid, di-C16-C18-alkyl esters (CAS No. 90193-76-3) was tested for its skin sensitisation potential according to OECD 406 (Pittermann, 1992). 10 guinea pigs were tested in a Buehler test. Concentrations for induction and challenge were defined in a preliminary experiment. Induction exposure was performed with the test substance at a concentration of 30 % in olive oil for epicutaneous application. Challenge treatment was performed by dermal application of the test substance at 10 % in olive oil. 24 and 48 hours after challenge exposure all skin examination scores in the test groups were zero. Based on this study results, 1,2 benzenedicarboxylic acid, di-C16-C18-alkyl esters exerted no skin-sensitising potential.

Migrated from Short description of key information:
The available skin sensitisation study showed that 1,2 benzenedicarboxylic acid, di-C16-C18-alkyl esters is not skin sensitising.

Justification for selection of skin sensitisation endpoint:
There is only one study available.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

The available data on the skin sensitisation potential do not meet the classification criteria according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification.

There are no data available on respiratory sensitisation.