Isophthaloyl dichloride

Repeated dose toxicity: dermal

Administrative data

Endpoint:

short-term repeated dose toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

significant methodological deficiencies

Remarks:

Limited exposure (2 hours/day), no pathology reported

Data source

Reference

Reference Type:

publication

Title:

Toxicity of isophthalic and terephthalic acid dichlorides

Author:

Sanina YP

Year:

1967

Bibliographic source:

Toksikol. Novykh. Prom. Khim., (9):158-163

Materials and methods

Principles of method if other than guideline:

The shaven skin area of rabbits was treated with 0.5 g of test substance and the area was sealed. Treatments were for 2 hours per day for 10 days.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Isophthaloyl dichloride

EC Number:

202-774-7

EC Name:

Isophthaloyl dichloride

Cas Number:

99-63-8

Molecular formula:

C8H4Cl2O2

IUPAC Name:

benzene-1,3-dicarbonyl dichloride

Test animals

Species:

rabbit

Administration / exposure

Type of coverage:

occlusive

Vehicle:

not specified

Details on exposure:

Route of Administration: dermal
Fur was removed from part of the back of the rabbits and a glass cap was firmly attached to the shaven skin area. There was a hole in the top of the cap, and the hole was stopped with a plug. After the cap was fastened, 0.5 g of the test substance was introduced through the hole, after which the cap was tightly sealed with the plug.

Duration of treatment / exposure:

10 days

Frequency of treatment:

2 hours/day for 10 days

Doses / concentrations

Dose / conc.:

0.5 other: g (nominal per unit area)

Control animals:

yes

Examinations

Observations and examinations performed and frequency:

Changes in body weight, the neuromuscular excitation threshold, and the skin temperature at the site of application of the test material were evaluated.

Results and discussion

Results of examinations

Details on results:

At the end of the 10 day exposure, deep fissures and separations of the superficial skin layers were seen in the rabbits. The wounds healed in 10-15 days after cessation of the exposure. A tendency toward elevation of the neuromuscular excitation threshold was seen at the end of the experimental period. The skin temperature at the application site was lower in experimental animals than controls. The difference reached nearly 1°C, beginning from the 7th day.

Effect levels

Dose descriptor:

NOAEL

Effect level:

> 0.5 other: g

Basis for effect level:

other: see 'Remark'

Target system / organ toxicity

Critical effects observed:

not specified