Registration Dossier
Registration Dossier
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EC number: 202-774-7 | CAS number: 99-63-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- No test article analysis. Non GLP. Non-guideline study design.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 960
- Report date:
- 1960
Materials and methods
- Principles of method if other than guideline:
- Groups of 1 rat exposed to 7 concentrations of the test substance. Mortality, clinical signs, and pathology were monitored and an oral ALD was reported.
- GLP compliance:
- no
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Isophthaloyl dichloride
- EC Number:
- 202-774-7
- EC Name:
- Isophthaloyl dichloride
- Cas Number:
- 99-63-8
- Molecular formula:
- C8H4Cl2O2
- IUPAC Name:
- benzene-1,3-dicarbonyl dichloride
- Details on test material:
- Test substance (as cited in study report): isophthaloyl chloride
Purity: not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: ChR
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- peanut oil
- Details on oral exposure:
- VEHICLE
25% Solution in Peanut Oil. - Doses:
- Single doses of 7500, 5000, 3400, 2250, 1500, 1000, 670 mg/kg
- No. of animals per sex per dose:
- 1
- Control animals:
- not specified
- Details on study design:
- No guidelines provided.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- other: Approximate Lethal Dose (ALD)
- Effect level:
- 5 000 mg/kg bw
- Mortality:
- 1/1 at 7500, 5000 mg/kg
0/1 at 3400, 2250, 1500, 1000, 670 mg/kg - Clinical signs:
- other: Discomfort and found dead following day: 7500, 5000 mg/kg doses Weight Loss: 3400, 2250 mg/kg No toxic signs observed: 1500, 1000, 670 mg/kg
- Gross pathology:
- Severe Injury to stomach: 7500, 5000 mg/kg doses
No pathological changes: 3400, 2250, 1500, 1000, 370 mg/kg doses
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Approximate Lethal Dose of the test substance was found to be 5000 mg/kg of body weight. Lethal doses caused severe gastritis. Clinical signs of toxicity were not observed in those rats receiving sublethal doses, nor was pathology observed when the rats were killed 10 days later.
- Executive summary:
Approximate Lethal Dose of the test substance was found to be 5000 mg/kg of body weight. Lethal doses caused severe gastritis. Clinical signs of toxicity were not observed in those rats receiving sublethal doses, nor was pathology observed when the rats were killed 10 days later.
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