Registration Dossier

Environmental fate & pathways

Adsorption / desorption

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Link to relevant study record(s)

Reference
Endpoint:
adsorption / desorption: screening
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study does not need to be conducted because the substance and its relevant degradation products decompose rapidly

Description of key information

IPA: logKoc = 1.0739 L/kg; Koc = 11.86 L/kg (QSAR)

Key value for chemical safety assessment

Koc at 20 °C:
11.86

Additional information

Since the substance rapidly hydrolyses in water, its environmental fate and distribution will be based on its primary degradate, isophthalic acid.

The relevant regression equation within KOCWIN v2.0 is: log Koc = 0.55313 log Kow + 0.9251 + correction factors (where n= 447, r2 = 0.855). This QSAR is preferred for use since an experimental value of logKow was available for IPA, logKow =1.66 (neutral form), and a correction factor is applied to account for IPA being an acid and therefore able to ionise. Since IPA lies within the domain of the QSAR as defined by the logKow and MW ranges, its prediction is considered valid for use.