3,5,5-trimethylhexanoyl chloride

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: limited documentation, however sufficient for endpoint evaluation

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3,5,5-trimethylhexanoyl chloride

EC Number:

253-168-4

EC Name:

3,5,5-trimethylhexanoyl chloride

Cas Number:

36727-29-4

Molecular formula:

C9H17ClO

IUPAC Name:

3,5,5-trimethylhexanoyl chloride

Details on test material:

TS-Freetext:
Isononansäurechlorid
- Name of test material (as cited in study report): Isononansaeurechlorid
- Physical state: liquid
- Analytical purity: 98 %

Test animals / tissue source

Species:

rabbit

Strain:

Vienna White

Details on test animals or tissues and environmental conditions:

TEST ANIMALS
- Source: Gaukler

Test system

Vehicle:

unchanged (no vehicle)

Controls:

other: the other eye of the same animals serves as control

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 µl

Observation period (in vivo):

8 days

Number of animals or in vitro replicates:

6

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

cornea opacity score

Basis:

mean

Time point:

24/48/72 h

Score:

0.33

Max. score:

4

Reversibility:

fully reversible within: 8 days

Remarks on result:

other: Onyl one animal showed slight reactions.

Results 2

Irritation parameter:

iris score

Basis:

mean

Time point:

24/48/72 h

Score:

0

Remarks on result:

not measured/tested

Results 3

Irritation parameter:

conjunctivae score

Basis:

animal #1

Time point:

24/48/72 h

Score:

2

Max. score:

4

Reversibility:

not fully reversible within: 8 days

Results 4

Irritation parameter:

conjunctivae score

Basis:

animal #2

Time point:

24/48/72 h

Score:

2

Max. score:

4

Reversibility:

not fully reversible within: 8 days

Results 5

Irritation parameter:

conjunctivae score

Basis:

animal #3

Time point:

24/48/72 h

Score:

1

Max. score:

4

Reversibility:

fully reversible within: 8 days

Results 6

Irritation parameter:

conjunctivae score

Basis:

animal #4

Time point:

24/48/72 h

Score:

1.33

Max. score:

4

Reversibility:

fully reversible

Results 7

Irritation parameter:

conjunctivae score

Basis:

animal #5

Time point:

24/48/72 h

Score:

1

Max. score:

4

Reversibility:

fully reversible

Results 8

Irritation parameter:

conjunctivae score

Basis:

animal #6

Time point:

24/48/72 h

Score:

1.33

Max. score:

4

Reversibility:

fully reversible

Results 9

Irritation parameter:

chemosis score

Basis:

animal #1

Time point:

24/48/72 h

Score:

1

Max. score:

4

Reversibility:

fully reversible within: 8 days

Results 10

Irritation parameter:

chemosis score

Basis:

animal #2

Time point:

24/48/72 h

Score:

1

Max. score:

4

Reversibility:

fully reversible within: 8 days

Results 11

Irritation parameter:

chemosis score

Basis:

animal #3

Time point:

24/48/72 h

Score:

0.67

Max. score:

4

Reversibility:

fully reversible within: 8 days

Results 12

Irritation parameter:

chemosis score

Basis:

animal #4

Time point:

24/48/72 h

Score:

0.67

Max. score:

4

Reversibility:

fully reversible

Results 13

Irritation parameter:

chemosis score

Basis:

animal #5

Time point:

24/48/72 h

Score:

0

Max. score:

4

Reversibility:

not specified

Results 14

Irritation parameter:

chemosis score

Basis:

animal #6

Time point:

24/48/72 h

Score:

0

Max. score:

4

Reversibility:

not specified

Any other information on results incl. tables

	Cornea			Iris	Conjunctiva
	Animal	Opacity	Aerea		Erythema	Edema	Discharge
24 h	1	0	0	0	2	1	1
	2	0	0	0	2	1	1
	3	0	0	0	1	0	1
	4	0	0	0	2	1	1
	5	0	0	0	2	0	0
	6	0	0	0	2	0	0
48 h	1	0	0	0	2	1	1
	2	0	0	0	2	1	1
	3	0	0	0	1	1	0
	4	0	0	0	1	1	1
	5	0	0	0	1	0	0
	6	0	0	0	1	0	0
72 h	1	0	0	0	2	1	1
	2	0	0	0	2	1	1
	3	0	0	0	1	1	0
	4	0	0	0	1	0	0
	5	1	2	0	0	0	0
	6	0	0	0	1	0	0
8 d	1	0	0	0	1	0	0
	2	0	0	0	1	0	0
	3	0	0	0	0	0	0
	4	-	-	-	-	-	-
	5	-	-	-	-	-	-
	6	-	-	-	-	-	-

mean (24/48/72 h)	1	0	0	0	2	1	1
	2	0	0	0	2	1	1
	3	0	0	0	1	0.67	0.33
	4	0	0	0	1.33	0.67	0.67
	5	0.33	0.67	0	1	0	0
	6	0	0	0	1.33	0	0