Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 253-168-4 | CAS number: 36727-29-4
Endpoint summary
Administrative data
Description of key information
3,5,5 trimethylhexanoyl chloride is very toxic at inhalation and of moderate toxicity after swallowing.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 1 700 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 0.24 mg/m³ air
Additional information
oral:
An acute oral toxicity study similar to OECD 401 with acceptable restrictions mostly due to reduced reporting in times before GLP was performed. Groups of 5 rats per sex and dose were administered with 3160, 2150, 1470, 1000 mg/kg of the test substance. The acute oral LD50 for male and female rats is ca. 1700 mg/kg after oral application (BASF 1979).
inhalation:
Five rats per sex and dose were exposed to 0.1, 0.24 and 0.45 mg/L (vapor; analytical conc.) for 1h in an OECD 403 guideline study. Irregular and accelerated respiration as well as eyelid closure, restlessness followed by apathy and abdominal position was observed. Necropsy of the animals that died showed general congestion (all animals) and intensified hyperemia of the lungs.
No macroscopic pathologic findings were noted in the animals killed at the end of the study. Combined LC50 value is about 0.24 mg/L/1h (BASF 1994)
Comparable results (LC50 0.1 mg/L/4h) were achieved in an non GLP study (BASF 1979).
Justification for classification or non-classification
According to the results the substance is classified as very toxic by inhalation cat 1 (H302) and harmful after swallowing cat 4 (H330) according of regulations 1272/2008/EC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
