Registration Dossier
Registration Dossier
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EC number: 253-168-4 | CAS number: 36727-29-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3,5,5-trimethylhexanoyl chloride
- EC Number:
- 253-168-4
- EC Name:
- 3,5,5-trimethylhexanoyl chloride
- Cas Number:
- 36727-29-4
- Molecular formula:
- C9H17ClO
- IUPAC Name:
- 3,5,5-trimethylhexanoyl chloride
- Details on test material:
- TS-Freetext:
Isononansäurechlorid
- Name of test material (as cited in study report): Isononansaeurechloid
- Physical state: liquid
- Analytical purity: 98 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 4.64 - 31.6 % solutionin olive oil - Doses:
- 3160, 2150, 1470, 1000 mg/kg body weight
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 700 mg/kg bw
- Mortality:
- see any other information below
- Clinical signs:
- other: staggering, atonia, excitement
- Gross pathology:
- sacrificed animals: nothing abnormal detected
Any other information on results incl. tables
Dose mg/kg bw |
Concentration |
Number of animals |
Died within 1 hour 24 hous 48 hours 7 days 14 days |
||||
3160 |
31.6 |
5 male 5 female |
0/5 0/5 |
5/5 5/5 |
5/5 5/5 |
5/5 5/5 |
5/5 5/5 |
2150 |
21.5 |
5 male 5 female |
0/5 0/5 |
3/5 4/5 |
4/5 5/5 |
4/5 5/5 |
4/5 5/5 |
1470 |
14.7 |
5 male 5 female |
0/5 0/5 |
0/5 1/5 |
0/5 1/5 |
0/5 2/5 |
0/5 2/5 |
1000 |
10 |
5 male 5 female |
0/5 0/5 |
0/5 0/5 |
0/5 0/5 |
0/5 0/5 |
0/5 0/5 |
Dose mg/kg bw |
Concentration |
Number of animals |
Died within 1 hour 24 hous 48 hours 7 days 14 days |
||||
3160 |
31.6 |
5 male 5 female |
0/5 0/5 |
5/5 5/5 |
5/5 5/5 |
5/5 5/5 |
5/5 5/5 |
2150 |
21.5 |
5 male 5 female |
0/5 0/5 |
3/5 4/5 |
4/5 5/5 |
4/5 5/5 |
4/5 5/5 |
1470 |
14.7 |
5 male 5 female |
0/5 0/5 |
0/5 1/5 |
0/5 1/5 |
0/5 2/5 |
0/5 2/5 |
1000 |
10 |
5 male 5 female |
0/5 0/5 |
0/5 0/5 |
0/5 0/5 |
0/5 0/5 |
0/5 0/5 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
