2,2-bis(hydroxymethyl)propionic acid

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Remarks:

For justification of read-across please refer to the attached read-across report and the study endpoint record: 'Source_Bioaccumulation:aquatic / sediment_2,2-bis(hydroxymethyl)butanoic acid.'

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Remarks:

Study data are included in the Japan CHEmicals Collaborative Knowledge database, a well established database where data are inspected and assessed for reliability before acceptance. Data were obtained via the OECD QSAR toolbox.

Justification for type of information:

For details and justification of read-across please refer to the report attached here.

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

OECD Guideline 305 (Bioaccumulation in Fish: Aqueous and Dietary Exposure) -I: Aqueous Exposure Bioconcentration Fish Test

Deviations:

not specified

GLP compliance:

not specified

Test organisms (species):

Cyprinus carpio

Route of exposure:

aqueous

Key result

Type:

BCF

Value:

< 62 L/kg

Validity criteria fulfilled:

yes

Conclusions:

It can be concluded that Bis-MPA has a low potential for bioaccumulation, based on read-across from a structurally similar substance with a BCF value of < 62 L/kg.

Executive summary:

This information is used in a read-across approach in the assessment of the target substance.

For justification of read-across please refer to the attached read-across report.

Reference 2

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2019

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Remarks:

Study data are included in the Japan CHEmicals Collaborative Knowledge database, a well established database where data are inspected and assessed for reliability before acceptance. Data were obtained via the OECD QSAR toolbox.

Qualifier:

according to guideline

Guideline:

OECD Guideline 305 (Bioaccumulation in Fish: Aqueous and Dietary Exposure) -I: Aqueous Exposure Bioconcentration Fish Test

Deviations:

not specified

GLP compliance:

not specified

Test organisms (species):

Cyprinus carpio

Route of exposure:

aqueous

Key result

Type:

BCF

Value:

< 62 L/kg

Validity criteria fulfilled:

yes

Conclusions:

In a bioaccumulation test performed according to OECD TG 305 on fish species Cyprinus carpio. 2,2-bis(hydroxymethyl)butanoic acid was found to have a low potential for bioaccumulation, based on a BCF value of < 62 L/kg

Executive summary:

A bioaccumulation test on 2,2-bis(hydroxymethyl)butanoic acid performed according to OECD TG 305 was available in the Japan CHEmicals Collaborative Knowledge database, a well established database where data are inspected and assessed for reliability before acceptance. Data were obtained through the OECD QSAR toolbox. The test, performed on Cyprinus carpio, resulted in a BCF value of < 62 L/kg, showing 2,2-bis(hydroxymethyl)butanoic acid has a low potential for bioaccumulation.

Description of key information

A read-across approach has been used to fulfill this endpoint. The justification for this approach is attached in the target endpoint record.

Key value for chemical safety assessment

BCF (aquatic species):

62 L/kg ww