Registration Dossier
Registration Dossier
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EC number: 225-306-3 | CAS number: 4767-03-7
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Remarks:
- For justification of read-across please refer to the attached read-across report and the study endpoint record: 'Source_Bioaccumulation:aquatic / sediment_2,2-bis(hydroxymethyl)butanoic acid.'
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- Study data are included in the Japan CHEmicals Collaborative Knowledge database, a well established database where data are inspected and assessed for reliability before acceptance. Data were obtained via the OECD QSAR toolbox.
- Justification for type of information:
- For details and justification of read-across please refer to the report attached here.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 (Bioaccumulation in Fish: Aqueous and Dietary Exposure) -I: Aqueous Exposure Bioconcentration Fish Test
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test organisms (species):
- Cyprinus carpio
- Route of exposure:
- aqueous
- Key result
- Type:
- BCF
- Value:
- < 62 L/kg
- Validity criteria fulfilled:
- yes
- Conclusions:
- It can be concluded that Bis-MPA has a low potential for bioaccumulation, based on read-across from a structurally similar substance with a BCF value of < 62 L/kg.
- Executive summary:
This information is used in a read-across approach in the assessment of the target substance.
For justification of read-across please refer to the attached read-across report.
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2019
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- Study data are included in the Japan CHEmicals Collaborative Knowledge database, a well established database where data are inspected and assessed for reliability before acceptance. Data were obtained via the OECD QSAR toolbox.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 (Bioaccumulation in Fish: Aqueous and Dietary Exposure) -I: Aqueous Exposure Bioconcentration Fish Test
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test organisms (species):
- Cyprinus carpio
- Route of exposure:
- aqueous
- Key result
- Type:
- BCF
- Value:
- < 62 L/kg
- Validity criteria fulfilled:
- yes
- Conclusions:
- In a bioaccumulation test performed according to OECD TG 305 on fish species Cyprinus carpio. 2,2-bis(hydroxymethyl)butanoic acid was found to have a low potential for bioaccumulation, based on a BCF value of < 62 L/kg
- Executive summary:
A bioaccumulation test on 2,2-bis(hydroxymethyl)butanoic acid performed according to OECD TG 305 was available in the Japan CHEmicals Collaborative Knowledge database, a well established database where data are inspected and assessed for reliability before acceptance. Data were obtained through the OECD QSAR toolbox. The test, performed on Cyprinus carpio, resulted in a BCF value of < 62 L/kg, showing 2,2-bis(hydroxymethyl)butanoic acid has a low potential for bioaccumulation.
Referenceopen allclose all
Description of key information
A read-across approach has been used to fulfill this endpoint. The justification for this approach is attached in the target endpoint record.
Key value for chemical safety assessment
- BCF (aquatic species):
- 62 L/kg ww
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
