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Bioaccumulation: aquatic / sediment

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Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Remarks:
For justification of read-across please refer to the attached read-across report and the study endpoint record: 'Source_Bioaccumulation:aquatic / sediment_2,2-bis(hydroxymethyl)butanoic acid.'
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Remarks:
Study data are included in the Japan CHEmicals Collaborative Knowledge database, a well established database where data are inspected and assessed for reliability before acceptance. Data were obtained via the OECD QSAR toolbox.
Justification for type of information:
For details and justification of read-across please refer to the report attached here.
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
OECD Guideline 305 (Bioaccumulation in Fish: Aqueous and Dietary Exposure) -I: Aqueous Exposure Bioconcentration Fish Test
Deviations:
not specified
GLP compliance:
not specified
Test organisms (species):
Cyprinus carpio
Route of exposure:
aqueous
Key result
Type:
BCF
Value:
< 62 L/kg
Validity criteria fulfilled:
yes
Conclusions:
It can be concluded that Bis-MPA has a low potential for bioaccumulation, based on read-across from a structurally similar substance with a BCF value of < 62 L/kg.
Executive summary:

This information is used in a read-across approach in the assessment of the target substance.


For justification of read-across please refer to the attached read-across report.

Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2019
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Remarks:
Study data are included in the Japan CHEmicals Collaborative Knowledge database, a well established database where data are inspected and assessed for reliability before acceptance. Data were obtained via the OECD QSAR toolbox.
Qualifier:
according to guideline
Guideline:
OECD Guideline 305 (Bioaccumulation in Fish: Aqueous and Dietary Exposure) -I: Aqueous Exposure Bioconcentration Fish Test
Deviations:
not specified
GLP compliance:
not specified
Test organisms (species):
Cyprinus carpio
Route of exposure:
aqueous
Key result
Type:
BCF
Value:
< 62 L/kg
Validity criteria fulfilled:
yes
Conclusions:
In a bioaccumulation test performed according to OECD TG 305 on fish species Cyprinus carpio. 2,2-bis(hydroxymethyl)butanoic acid was found to have a low potential for bioaccumulation, based on a BCF value of < 62 L/kg
Executive summary:

A bioaccumulation test on 2,2-bis(hydroxymethyl)butanoic acid performed according to OECD TG 305 was available in the Japan CHEmicals Collaborative Knowledge database, a well established database where data are inspected and assessed for reliability before acceptance. Data were obtained through the OECD QSAR toolbox. The test, performed on Cyprinus carpio, resulted in a BCF value of < 62 L/kg, showing 2,2-bis(hydroxymethyl)butanoic acid has a low potential for bioaccumulation.

Description of key information

A read-across approach has been used to fulfill this endpoint. The justification for this approach is attached in the target endpoint record.

Key value for chemical safety assessment

BCF (aquatic species):
62 L/kg ww

Additional information