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Physical & Chemical properties

Melting point / freezing point

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Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Reason / purpose:
reference to same study
Reason / purpose:
reference to same study
Qualifier:
equivalent or similar to
Guideline:
other: no guideline reported
Principles of method if other than guideline:
Data from Handbook.
No Guideline mentioned
GLP compliance:
not specified
Type of method:
other: not specified
Key result
Melting / freezing pt.:
ca. 303 °C
Decomposition:
yes
Decomp. temp.:
303 °C
Conclusions:
The melting point of Creatine is 303°C (with decomposition).
Executive summary:

A melting point of 303°C (with decomposition) for Creatine is reported by the CRC Handbook of Chemicals and Physics (92nd edition).

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
In order to measure the melting point of a substance, the sample is continuously heated and the temperature of the phase transition from the solid to the liquid state is determined. The Melting point of Creatine monohydrate is reported to be between 301 °C (Degussa Safety Data Sheet for Creapure (= Creatine monohydrate), 2003) and 303 °C (Lewis, R.J., Sr. (Ed.). Hawley's Condensed Chemical Dictionary, 13th ed. New York, NY: John Wiley & Sons, Inc. 1997, p. 309: decomposition at 303 °C). At elevated temperatures (~ 100 °C) the crystallization water is evaporated and Creatine is generated from Creatine monohydrate (Singh, 2009).
Principles of method if other than guideline:
secondary literature; method not reported
GLP compliance:
not specified
Type of method:
other: secondary literature; method not reported
Melting / freezing pt.:
300 °C
Decomposition:
yes
Decomp. temp.:
300 °C
Remarks on result:
other: Creatine monohydrate dehydrates to anhydrous creatine at 100 °C and finally melts at 300 °C with decomposition.
Conclusions:
Creatine monohydrate dehydrates to anhydrous creatine at 100 °C and finally melts at 300 °C with decomposition.
Executive summary:

Singh & Dash, 2009 (secondary literature) report that creatine monohydrate dehydrates to anhydrous creatine at 100 °C and finally melts at 300 °C with decomposition.

Description of key information

Creatine melts at 300-303°C with decomposition.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
302 °C

Additional information

The Hazardous Substances Data Bank (HSDB), a data bank providing peer-reviewed data on various substances cites Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary(13th ed. New York, NY: John Wiley & Sons, Inc. 1997., p. 309) which states that creatine decomposes at 303 °C.

This data is supported by the information from the Degussa 2003 Safety Data Sheet which states a melting point of 301 °C for creapure (creatine monohydrate). In a read-across approach this information was used for creatine because creatine monohydrate dehydrates to anhydrous creatine at 100 °C (see Singh & Dash, 2009).

Singh & Dash report creatine to melt at 300 °C with decomposition.

The value reported in the CRC handbook 2011 is reported to be 303 °C (with decomposition).

The mean value of all four reported values (-> 302 °C) is used as key value in the Chemical Safety Assessment.