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EC number: 200-306-6 | CAS number: 57-00-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: no guideline reported
- Principles of method if other than guideline:
- Data from Handbook.
No Guideline mentioned - GLP compliance:
- not specified
- Type of method:
- other: not specified
- Key result
- Melting / freezing pt.:
- ca. 303 °C
- Decomposition:
- yes
- Decomp. temp.:
- 303 °C
- Conclusions:
- The melting point of Creatine is 303°C (with decomposition).
- Executive summary:
A melting point of 303°C (with decomposition) for Creatine is reported by the CRC Handbook of Chemicals and Physics (92nd edition).
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- In order to measure the melting point of a substance, the sample is continuously heated and the temperature of the phase transition from the solid to the liquid state is determined. The Melting point of Creatine monohydrate is reported to be between 301 °C (Degussa Safety Data Sheet for Creapure (= Creatine monohydrate), 2003) and 303 °C (Lewis, R.J., Sr. (Ed.). Hawley's Condensed Chemical Dictionary, 13th ed. New York, NY: John Wiley & Sons, Inc. 1997, p. 309: decomposition at 303 °C). At elevated temperatures (~ 100 °C) the crystallization water is evaporated and Creatine is generated from Creatine monohydrate (Singh, 2009).
- Principles of method if other than guideline:
- secondary literature; method not reported
- GLP compliance:
- not specified
- Type of method:
- other: secondary literature; method not reported
- Melting / freezing pt.:
- 300 °C
- Decomposition:
- yes
- Decomp. temp.:
- 300 °C
- Remarks on result:
- other: Creatine monohydrate dehydrates to anhydrous creatine at 100 °C and finally melts at 300 °C with decomposition.
- Conclusions:
- Creatine monohydrate dehydrates to anhydrous creatine at 100 °C and finally melts at 300 °C with decomposition.
- Executive summary:
Singh & Dash, 2009 (secondary literature) report that creatine monohydrate dehydrates to anhydrous creatine at 100 °C and finally melts at 300 °C with decomposition.
Referenceopen allclose all
Description of key information
Creatine melts at 300-303°C with decomposition.
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 302 °C
Additional information
The Hazardous Substances Data Bank (HSDB), a data bank providing peer-reviewed data on various substances cites Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary(13th ed. New York, NY: John Wiley & Sons, Inc. 1997., p. 309) which states that creatine decomposes at 303 °C.
This data is supported by the information from the Degussa 2003 Safety Data Sheet which states a melting point of 301 °C for creapure (creatine monohydrate). In a read-across approach this information was used for creatine because creatine monohydrate dehydrates to anhydrous creatine at 100 °C (see Singh & Dash, 2009).
Singh & Dash report creatine to melt at 300 °C with decomposition.
The value reported in the CRC handbook 2011 is reported to be 303 °C (with decomposition).
The mean value of all four reported values (-> 302 °C) is used as key value in the Chemical Safety Assessment.
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