N-amidinosarcosine

Auto flammability

Link to relevant study record(s)

Reference

Endpoint:

relative self-ignition temperature (solids)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2011-09-23 to 2011-09-30

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Creatine is manufactured by drying of creatine monohydrate. The only difference between creatine and creatine monohydrate is the water content of the substances. Creatine (C4H9N3O2) does not contain water molecules, whereas creatine monohydrate contains one water molecule per substance molecule (C4H9N3O2 x H2O). At elevated temperatures (~ 100 °C) the crystallization water is evaporated and Creatine is generated from Creatine monohydrate. Consequently, the self-ignition temperature of the anhydrous form Creatine is determined in this test. It can be therefore stated, that Creatine is not self-ignitable in the temperature range ~ 100°C to 400°C.

Qualifier:

according to guideline

Guideline:

EU Method A.16 (Relative Self-Ignition Temperature for Solids)

Deviations:

no

GLP compliance:

not specified

Key result

Relative self-ignition temperature:

> 400 °C

Remarks on result:

no self ignition observed under the test conditions

In the temperature range of 22 °C to 400 °C no exothermic reaction (only two endothermic reactions) was visible.

Conclusions:

According to the definition in Council Regulation (EC) No 440/2008, method A.16, the test item has to be considered as not self-ignitable.

Executive summary:

The purpose of this test was to provide information on the auto-flammability of Creatine Monohydrate at elevated temperatures.

According to EC-Guideline, test method A.16, the relative self-ignition temperature of a substance is the minimum environmental temperature in °C units at which the substance is ignited under defined conditions.

In the temperature range of 22 °C to 400 °C no exothermic reaction (only two endothermic reactions) was visible.

Thus, Creatine Monohydrate is not self-ignitable in the temperature range 22°C to 400°C.

Description of key information

Creatine monohydrate was tested according to EC guideline, test method A.16 for auto flammability at elevated temperatures.

The test item is not considered as self-ignitable. This information is used for read-across to creatine.

Additional information

Creatine monohydrate was tested according to EC guideline, test method A.16 for auto flammability at elevated temperatures. In the temperature range of 22 °C to 400 °C no exothermic reaction (only two endothermic reactions) was visible.

Thus, Creatine Monohydrate is not self-ignitable in the temperature range 22°C to 400°C.