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Physical & Chemical properties

Dissociation constant

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Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
equivalent or similar to
Guideline:
other: no guideline reported
Principles of method if other than guideline:
no data; handbook
GLP compliance:
not specified
Dissociating properties:
yes
No.:
#1
pKa:
2.63
Temp.:
25 °C
No.:
#2
pKa:
14.3
Temp.:
25 °C
Conclusions:
Creatine dissociates in 2 steps:
- step 1: pKa = 2.63 (25 °C)
- step 2: pKa = 14.3 (25 °C)
Executive summary:

The CRC Handbook of chemistry and physics 92 nd edition (2011-2012) (5-96) reports the following dissociation constants for creatine:

- step 1: pKa = 2.63 (25°C);

- step 2: pKa = 14.3 (25°C)

Description of key information

The CRC Handbook of chemistry and physics 92 nd edition (2011-2012) (5-96) reports the following dissociation constants for creatine:
- step 1: pKa = 2.63 (25°C);
- step 2: pKa = 14.3 (25°C)

Key value for chemical safety assessment

Additional information