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Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
JAN 2013 - MAR 2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
GLP compliance:
yes
Radiolabelling:
no
Analytical monitoring:
yes
Buffers:
Buffer pH 4,
Buffer pH 7,
Buffer pH 9,
Duration:
168 h
pH:
4
Initial conc. measured:
> 0.09 - < 0.107 g/L
Duration:
120 h
pH:
7
Initial conc. measured:
> 0.1 - < 0.1 g/L
Duration:
120 h
pH:
9
Initial conc. measured:
> 0.096 - < 0.096 g/L
Number of replicates:
2 replicates per pH value
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
% Recovery:
> 99.5
pH:
4
Temp.:
50 °C
Duration:
168 h
% Recovery:
> 99.7 - < 103
pH:
7
Temp.:
50 °C
Duration:
120 h
% Recovery:
> 108 - < 115
pH:
9
Temp.:
50 °C
Duration:
120 h
Key result
pH:
4
Temp.:
25 °C
DT50:
> 1 yr
Type:
not specified
Remarks on result:
other: Estimated from results at 50 ºC
Key result
pH:
7
Temp.:
25 °C
DT50:
> 1 yr
Type:
not specified
Remarks on result:
other: Estimated from results at 50 ºC
Key result
pH:
9
Temp.:
25 °C
DT50:
> 1 yr
Type:
not specified
Remarks on result:
other: Estimated from results at 50 ºC
Validity criteria fulfilled:
yes
Conclusions:
The test item was found not to hydrolyse at pH 4 - 7 - 9, half-life greater than 1 year at 25 ºC
Executive summary:

Hydrolysis test was done according to OECD Guideline 111. The test item was found not to hydrolyse at pH 4 - 7 - 9, half-life greater than 1 year at 25 ºC

Description of key information

Hydrolysis test was done according to OECD Guideline 111. The test item was found not to hydrolyse at pH 4 - 7 - 9, half-life greater than 1 year at 25 ºC

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
25 °C

Additional information