Registration Dossier
Registration Dossier
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EC number: 203-139-7 | CAS number: 103-73-1
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia"
- Author:
- Bandman A.L. et al.
- Year:
- 1 994
- Bibliographic source:
- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,289,1994
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : BZ8050000
- Author:
- RTECS database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances):- VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". Bandman A.L. et al., Chimia, 1994. Volume(issue)/page/year: -,289,1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from RTECS database
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Anisole
- EC Number:
- 202-876-1
- EC Name:
- Anisole
- Cas Number:
- 100-66-3
- Molecular formula:
- C7H8O
- IUPAC Name:
- methoxybenzene
- Details on test material:
- Substance Name: anisole
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 122 days
- Frequency of treatment:
- Intermittent
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- other: TCLo
- Effect level:
- 200 mg/m³ air
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: not specified
Target system / organ toxicity
- Critical effects observed:
- not specified
- System:
- other: not specified
- Organ:
- not specified
- Treatment related:
- not specified
- Dose response relationship:
- not specified
- Relevant for humans:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The repeated dose toxicity TCLo(Lowest published toxic concentration) of anisole was observed at a dose concentration of 200 mg/m3 air in a 122 days study period where the dosage of anisole was intermittently given to rodent-rat by inhalative route.This indicates that anisole shall not exhibit toxic effect to rodent-rat by the inhalative route below the above mention dose.
- Executive summary:
The repeated dose toxicity TCLo(Lowest published toxic concentration) of anisole was observed at a dose concentration of 200 mg/m3 air in a 122 days study period where the dosage of anisole was intermittently given to rodent-rat by inhalative route.This indicates that anisole shall not exhibit toxic effect to rodent-rat by the inhalative route below the above mention dose.
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