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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
No information
Author:
Chapman and Hall
Year:
1959
Bibliographic source:
Williams, R. T. Detoxication Mechanisms 1959, Chapman and Hall, London, UK.
Reference Type:
review article or handbook
Title:
DOSE Doc. no.: P73
Author:
RSC Publishing
Year:
2011
Bibliographic source:
Dictionary of Substances and their effects (DOSE);Williams, R. T. Detoxication Mechanisms 1959, Chapman and Hall, London, UK.
Reference Type:
other: Authoritative data base
Title:
HSDB Number : 112
Author:
HSDB database
Year:
2011
Bibliographic source:
HSDB (Hazardous Substances Data Bank); US national Library of Medicine reviewed by SRC:-Clayton, G. D. and F. E. Clayton (eds.). Patty's Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982; p.2525
Reference Type:
other: Authoritative data base
Title:
GCID : 11048
Author:
ACToR database
Year:
2011
Bibliographic source:
ACToR (Aggregated Computational Toxicology Resource):-[Clayton, G. D. and F. E. Clayton (eds.). Pattys Industrial Hygiene and Toxicology: Volume 2A, 2B, 2C: Toxicology. 3rd ed. New York: John Wiley Sons, 1981-1982., p. 2525]**PEER REVIEWED**

Materials and methods

Objective of study:
excretion
Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is taken from DOSE handbook and HSDB, ACToR database
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Phenetole
EC Number:
203-139-7
EC Name:
Phenetole
Cas Number:
103-73-1
Molecular formula:
C8H10O
IUPAC Name:
ethoxybenzene
Details on test material:
- Name of test material (as cited in study report): Phenetole
- Substance type: Organic
- Physical state: Liquid
Radiolabelling:
not specified

Test animals

Species:
other: no data
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: no data
Vehicle:
not specified
Control animals:
not specified

Results and discussion

Main ADME resultsopen allclose all
Type:
metabolism
Results:
Hydroxylated in the para position
Type:
excretion
Results:
excreted as glucuronide and ethereal sulfate

Toxicokinetic / pharmacokinetic studies

Details on excretion:
Phenetole, like Anisole, is hydroxylated in para position & excreted as glucuronide & ethereal sulfate

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
glucuronide and ethereal sulfate

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): low bioaccumulation potential based on study results
Phenetole is hydroxylated in its para position & excreted as metabolites glucuronide & ethereal sulfate. Also, the bio-accumulation potential of the chemical varied from 21 to 48 (very low value that does not suggest bio-accumulation). Thus, considering these facts, the bio-accumulation potential of phenetole appears to be low.
Executive summary:

Phenetole is hydroxylated in its para position & excreted as metabolites glucuronide & ethereal sulfate. Also, the bio-accumulation potential of the chemical varied from 21 to 48 (very low value that does not suggest bio-accumulation). Thus, considering these facts, the bio-accumulation potential of phenetole appears to be low.