Registration Dossier
Registration Dossier
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EC number: 211-519-9 | CAS number: 657-27-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Based on all the in vitro data available there is no need to perform in vivo testing.
Short description of key information:
Several in vitro tests are available. L-Lysine HCL was not mutagenic in four Ames tests performed according to OECD 471 with and without metabolic activation. A chromosomal aberration test according to OECD 473 showed lysine HCl to be not clastogenic. L-Lysine HCl was not clastogenic or aneugenic in an in vitro micronucleus test performed according to OECD 487 (draft). L-Lysine HCl was not mutagenic at the Tk-locus of mouse lymphoma L5178Y cells in two tests performed according to OECD 476.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Based on the in vitro data available, L-lysine HCl does not have to be classified (DSD and CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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