Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-519-9 | CAS number: 657-27-2
Endpoint summary
Administrative data
Description of key information
The acute toxicity of L-lysine hydrochloride to Oryzias latipes (1 replicate/concentration, 10 fish/concentration) was assessed in a semi-static test according to OECD 203. The nominal test concentration was 100 mg/L. Measured concentrations in freshly prepared and used (24h after the test solution was prepared) ranged between 99% and 103% of nominal.The LC50 was >103 mg/L, based on averaged measured concentrations.
The acute toxicity of L- lysine hydrochloride to Daphnia magna(< 24 old, 4 replicates/concentration, 5 daphnids/replicate) was assessed in a semi- static test according to OECD 202. The nominal test concentration was 100 mg/L. Measured concentrations in freshly prepared solutions (0 and 24 hours) and 24- hour spent solutions (24 and 48 hours) ranged between 105 and 108% of nominal.The EC50 was >106 mg/L, based on mean measured concentrations.
The acute toxicity of L-lysine hydrochloride to Pseudokirchneriella subcapitata (6 replicates/concentration, intial biomass 1 x 104cells/mL) was assessed according to OECD 201. The nominal test concentration was 100 mg/L. Measured concentrations of the test substance in the test solutions during the exposure period were well maintained, i.e. within range of 99 - 102 % of the nominal value. Average measured concentration during the exposure period was 100 mg /L. The ErC50 (0 -72h) was >100 mg/L and NOECr (0 -72h) was 100 mg/L.
L-Lysine Monohydrochloride was not toxic to waste water (activated sludge) bacteria at a nominal concentration of 100 mg/l (EC50 > 100 mg/l). No (significant) inhibition of respiration rate of the sludge was recorded at 100 mg L-Lysine Monohydrochloride per litre. The duplicate measurement confirmed the result of the first measurement. Therefore, no further testing was needed. Hence, the EC50 of L-Lysine Monohydrochloride exceeded 100 mg/l (based on nominal concentrations).
Additional information
L-Lysine-HCl shows no aquatic toxicity in acute testing.
Long-term testing
In Annex IX REACH, it is laid down that long-term toxicity testing shall be proposed by the registrant if the CSA indicates the need to investigate further the effects. According to Annex I of REACH, the CSA triggers further action when the substance fulfils the criteria for any of most hazard classes or categories set out in Annex I to Regulation (EC) No. 1272/2008 (for details see REACH Annex I section 0.6.3.) or is assessed to be a PBT or vPvB.
The hazard assessment reveals neither a need to classify the substance as dangerous to the environment, nor is it a PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment.
Therefore, and for reasons of animal welfare, a long-term toxicity testing is not required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
