Registration Dossier
Registration Dossier
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EC number: 213-554-5 | CAS number: 976-71-6
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: short abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicologic evaluation of aldadiene
- Author:
- McLain DE et al.
- Year:
- 1 990
- Bibliographic source:
- J. American College Toxicology, Part B. Vol. 1, pp. 36-37, 1990
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- Canrenone
- EC Number:
- 213-554-5
- EC Name:
- Canrenone
- Cas Number:
- 976-71-6
- Molecular formula:
- C22H28O3
- IUPAC Name:
- 10,13-dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione
- Reference substance name:
- Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, .gamma.-lactone
- IUPAC Name:
- Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, .gamma.-lactone
- Test material form:
- solid - liquid: suspension
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- male/female
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: according to the method of Magnusson and Kligman (1969)
- Vehicle:
- other: propylene glycol (1st induction), petrolatum (2nd induction, glycerine (challenge)
- Concentration / amount:
- 1st induction (day 0): 5 % ;
2nd induction (day 7): 10 % ;
challenge (day 21): 2.5 %
Challengeopen allclose all
- Route:
- other: according to the method of Magnusson and Kligman (1969)
- Vehicle:
- other: propylene glycol (1st induction), petrolatum (2nd induction, glycerine (challenge)
- Concentration / amount:
- 1st induction (day 0): 5 % ;
2nd induction (day 7): 10 % ;
challenge (day 21): 2.5 %
- No. of animals per dose:
- 30 (15 per sex)
- Details on study design:
- no data
- Challenge controls:
- no data
- Positive control substance(s):
- not specified
Results and discussion
- Positive control results:
- no data
Any other information on results incl. tables
No contact sensitisation. Potential for mild irritation.
Applicant's summary and conclusion
- Executive summary:
In a guinea pig maximization test (GPMT) the test substance revealed no skin sensitising potential. A potential for mild irritation was observed.
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