Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics, other
Type of information:
other: toxicokinetic assessment
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Assessment is perfomed using available information on substance properties

Data source

Reference
Reference Type:
other: toxicokinetic assessment
Title:
Unnamed
Year:
2013

Materials and methods

Objective of study:
toxicokinetics
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
toxicokinetic assessment of the available information and physico-chemical properties
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-azobis[2-methylpropionamidine] dihydrochloride
EC Number:
221-070-0
EC Name:
2,2'-azobis[2-methylpropionamidine] dihydrochloride
Cas Number:
2997-92-4
Molecular formula:
C8H18N6.2ClH
IUPAC Name:
2,2'-diazene-1,2-diylbis(2-methylpropanimidamide) dihydrochloride
Constituent 2
Reference substance name:
2,2'-azobis(2-amidinopropane)-dihydrochloride
IUPAC Name:
2,2'-azobis(2-amidinopropane)-dihydrochloride
Test material form:
other: granules
Details on test material:
- Name of test material (as cited in study report): 2,2'-azobis(2-amidinopropane)-dihydrochloride
- Substance type: organic
- Physical state: solid
- Analytical purity: 99.1 %
- Lot/batch No.: I59596
- Expiration date of the lot/batch: 31. Dec. 2012
- Storage condition of test material: ambient temperature, dark

Results and discussion

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
Based on the physicochemical data the toxicokinetic properties of 2,2’-Azobis(2-amidinopropane) dihydrochloride are assessed.
Executive summary:

Absorption: for the dermal and oral route, an absorption of 100% are assumed,

for the inhalative route no relevant absorption is estimated and 10% are assumed.

Distribution: no information

Metabolism and Excretion: Phase II reactions may occur.

Renale and fecal excretion are the prominent excretion routes.